The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review

Title:The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review

Volume: 19 Issue: 8

Author(s): Mandana Lotfi, Amir Hosseyn Hasanpour, Ali Akbar Moghadamnia and Sohrab Kazemi*

Affiliation:

• Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol,Iran

Keywords: Nonylphenol, neurotoxicity, hippocampus, oxidative stress, neuro inflammation, apoptosis.

Abstract:

Background: Nonylphenol (NP), a chemical compound widely used in industry, is the result of the nonylphenol ethoxylate decomposition and it is known as an estrogen-like compound. Numerous studies and researches have shown that it has many destructive functions of various organs such as the brain. This toxicant causes oxidative stress in the cortex and hippocampus cells, which are two essential regions to preserve memory and learning in the brain.

Methods: This review examines recent findings to better understanding the mechanisms of NP neurotoxicity. We used Scopus, Google Scholar, and PubMed databases to find articles focused on the destructive effects of NP on the oxidative stress pathway and its defense mechanisms.

Results: NP has potential human health hazards associated with gestational, peri- and postnatal exposure. NP can disrupt brain homeostasis in different ways, such as activation of inflammatory factors in brain especially in hippocampus and cortex, disruption of the cell cycle, changes in neuron, dendrites and synapses morphology, disruption of extra and intracellular calcium ion balance and also memory and learning disorders.

Cite this article as:

Lotfi Mandana , Hasanpour Hosseyn Amir , Moghadamnia Akbar Ali and Kazemi Sohrab *, The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review, Current Neuropharmacology 2021; 19 (8) . https://dx.doi.org/10.2174/1570159X18666201119160347