Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

Title:Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

Volume: 20 Issue: 2

Author(s): Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu and Yi Li*

Affiliation:

• Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing,China

Keywords: Hyperammonemia, intestinal flora imbalance, inflammatory medium, neurotransmitters, sepsis-associated encephalopathy, mitochondrial dysfunction.

Abstract: Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

Cite this article as:

Zhao Lina , Gao Yanxia , Guo Shigong , Lu Xin , Yu Shiyuan , Ge Zheng Zeng , Zhu Dong Hua and Li Yi *, Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis, CNS & Neurological Disorders - Drug Targets 2021; 20 (2) . https://dx.doi.org/10.2174/1871527319999201117122158