Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair

Title:Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair

Volume: 19 Issue: 12

Author(s): Andrea Raspa and Fabrizio Gelain*

Affiliation:

• Tissue Engineering Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapies-ISBReMIT, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG),Italy

Keywords: Biomaterial, nervous regeneration, cell-matrix interactions, surface modification, self-assembling peptides, biomimetics.

Abstract: Extracellular matrix (ECM) consists of proteins, proteoglycans, and different soluble molecules. ECM provides structural support to mammalian cells. ECM is responsible for important cell functions, as well as assembling cells into various tissues and organs, regulating growth and cell-cell interaction. Recent studies have shown the potential of nanostructured biomaterials to mimic native ECM. Developing tailor-made biomaterials that mimic the complex nanoscale mesh of local ECM is not a trivial endeavor: bio-inspired biomaterials are designed to supply a healthy ECMlike structure, capable of filling the lesion cavity, favoring transplanted cell engraftment, providing physical support to endogenous neurogenesis and also tuning the inflammatory response to protect spared neurons. The strategies used to manufacture biomimetic hydrogel scaffold represent particularly important prospects of novel therapies for CNS regeneration. During this review, we describe with details the most promising regulatory pathways from ECM involved in the CNS injury and regeneration and we draw a line to the biomimetic potential of engineered nanostructured biomaterials aimed at mimicking extracellular matrix constructs and favoring the release of pro-regenerative agents. Lastly, a brief overview of their application in clinical trials is provided.

Cite this article as:

Raspa Andrea and Gelain Fabrizio *, Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair, Current Neuropharmacology 2021; 19 (12) . https://dx.doi.org/10.2174/1570159X18666201111111102