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Research Article

MIF 在硫代乙酰胺诱导的小鼠肝损伤肝功能、氧化应激和炎症中的作用：甜菜碱的保护作用

卷 28, 期 16, 2021

发表于: 04 November, 2020

页: [3249 - 3268] 页: 20

弟呕挨: 10.2174/0929867327666201104151025

价格: $65

摘要

背景：巨噬细胞迁移抑制因子 (MIF) 是一种多能细胞因子，有助于化学性肝损伤的炎症反应。这种细胞因子根据肝病的病因和阶段表现出促炎和抗炎作用。 目的：我们的研究旨在研究 MIF 在氧化应激和肝脏炎症中的作用，以及甜菜碱对硫代乙酰胺 (TAA) 诱导的小鼠慢性肝损伤中 MIF 的调节作用。 方法：实验在野生型和敲除型 MIF-/- C57BL/6 小鼠上进行。它们被分为以下几组：对照；接受甜菜碱的 Bet 组（溶于饮用水中的 2% wt/v）； MIF-/-小鼠组； MIF-/-+投注；接受 TAA (200 mg/kg b.w.)，腹膜内，3x/周/8 周的 TAA 组； TAA+投注； MIF-/-+TAA 和 MIF-/-+TAA+Bet。在 TAA 和 Bet 治疗组中，动物接受相同的剂量。治疗八周后，采集血样进行生化分析，并制备肝脏标本用于评估氧化应激和炎症参数。 结果：在 MIF-/-小鼠中，TAA 降低转氨酶、γ-谷氨酰转肽酶、胆红素、丙二醛 (MDA)、氧化蛋白产物 (AOPP)、总氧化状态 (TOS)、C 反应蛋白 (CRP)、IL-6、 IFN-γ，以及增加的硫醇和总抗氧化状态 (TAS)。甜菜碱减弱了 MIF 的机制和 TAA 诱导的肝损伤中的介导作用，降低了转氨酶、γ-谷氨酰转肽酶、胆红素、MDA、AOPP、TOS、CRP、IL-6、IFN-g 和增加硫醇。结论：MIF 是 TAA 诱导的肝损伤的肝毒性、促氧化和促炎作用的介质。 MIF 靶向治疗可以潜在地减轻肝脏中的氧化应激和炎症，但其作用的确切机制需要进一步研究。甜菜碱可增强抗氧化防御并减弱 MIF 的肝毒性作用，表明甜菜碱可用于预防和治疗肝损伤。

关键词: 硫代乙酰胺、肝损伤、炎症、巨噬细胞迁移抑制因子、甜菜碱、小鼠。

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