Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines:Small Molecules with Great Potential

Title: Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines:Small Molecules with Great Potential

Volume: 10 Issue: 10

Author(s): Jennifer C. O'Neill and Helen E. Blackwell

Affiliation:

Keywords: Diketopiperazine (DKP), microwave (MW)-assisted organic reaction, cyclative cleavage, privileged structure, solid-phase organic synthesis (SPOS), small molecule therapeutic

Abstract: Diketopiperazines (DKPs) are a well-known class of heterocycles that have recently emerged as a promising biologically active scaffold. Solid-phase organic synthesis has become an important tool in the combinatorial exploration of these privileged structures, expediting the synthesis and, therefore, the discovery of active compounds. To date, certain DKPs have shown potent activities against a range of diseases and biological phenomena, including bacterial infections, various cancers, asthma, infertility, premature labor, and HIV. Recent applications of solid-phase DKP synthesis, with a particular focus on cyclative cleavage and microwave-assisted reactions, are highlighted herein.

Cite this article as:

O'Neill C. Jennifer and Blackwell E. Helen, Solid-Phase and Microwave-Assisted Syntheses of 2,5-Diketopiperazines:Small Molecules with Great Potential, Combinatorial Chemistry & High Throughput Screening 2007; 10 (10) . https://dx.doi.org/10.2174/138620707783220365