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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Review Article

Ultrasound Diagnostic Method in Vascular Dementia: Current Concepts

Author(s): Antonio Siniscalchi*, Cleona Gray and Giovanni Malferrari

Volume 17, Issue 4, 2021

Published on: 08 October, 2020

Page: [507 - 512] Pages: 6

DOI: 10.2174/1573405616999201008145106

Price: $65

Abstract

Background: Increasing interest in identifying cerebral hemodynamics alterations as a cause of possible onset or worsening of cognitive impairment in elderly patients with vascular risk factors.

Introduction: Intracranial ultrasound is a non-invasive, repeatable inexpensive method for recording variation of the cerebral vascular tree in physiological and pathological conditions and the diagnosis of vascular dementia (VaD).

Methods: PubMed, Embase, Cochrane library and reference lists have been searched for articles published until March 30, 2020.

Results: Clinical studies reported different Transcranial Doppler (TCD) parameters and subsequently transcranial duplex with color code (TCCD) in patients affected by vascular dementia. The number of studies using TCCD remains limited and most of the available data are still based on TCD. However, the use of transcranial Doppler could better stratify elderly patients with initial signs of cognitive impairment.

Conclusion: Intracranial ultrasound employment to detect cerebral hemodynamic changes in VaD patients has been briefly discussed in this review.

Keywords: Ultrasound diagnostic method, neurosonology, transcranial doppler, transcranial duplex color code, vascular dementia, elderly patients.

Graphical Abstract

[1]
van Oijen M, de Jong FJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Atherosclerosis and risk for dementia. Ann Neurol 2007; 61(5): 403-10.
[http://dx.doi.org/10.1002/ana.21073] [PMID: 17328068]
[2]
Bakker FC, Klijn CJ, Jennekens-Schinkel A, Kappelle LJ. Cognitive disorders in patients with occlusive disease of the carotid artery: a systematic review of the literature. J Neurol 2000; 247(9): 669-76.
[http://dx.doi.org/10.1007/s004150070108] [PMID: 11081804]
[3]
Iadecola C. Hypertension and dementia. Hypertension 2014; 64(1): 3-5.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03040] [PMID: 24777976]
[4]
Vinciguerra L, Lanza G, Puglisi V, et al. Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia. PLoS One 2019; 14(4): e0216162.
[http://dx.doi.org/10.1371/journal.pone.0216162] [PMID: 31017968]
[5]
Beishon L, Haunton VJ, Panerai RB, Robinson TG. Cerebral hemodynamics in mild cognitive impairment: A systematic review. J Alzheimers Dis 2017; 59(1): 369-85.
[http://dx.doi.org/10.3233/JAD-170181] [PMID: 28671118]
[6]
López-Olóriz J, López-Cancio E, Arenillas JF, et al. Asymptomatic cervicocerebral atherosclerosis, intracranial vascular resistance and cognition: the AsIA-neuropsychology study. Atherosclerosis 2013; 230(2): 330-5.
[http://dx.doi.org/10.1016/j.atherosclerosis.2013.08.011] [PMID: 24075765]
[7]
Montagne A, Barnes SR, Sweeney MD, et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 2015; 85(2): 296-302.
[http://dx.doi.org/10.1016/j.neuron.2014.12.032] [PMID: 25611508]
[8]
Yang T, Sun Y, Lu Z, Leak RK, Zhang F. The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev 2017; 34: 15-29.
[http://dx.doi.org/10.1016/j.arr.2016.09.007] [PMID: 27693240]
[9]
Demarin V, Morovic S. Ultrasound subclinical markers in assessing vascular changes in cognitive decline and dementia. J Alzheimers Dis 2014; 42(Suppl. 3): S259-66.
[http://dx.doi.org/10.3233/JAD-132507] [PMID: 24603944]
[10]
Siniscalchi A, Malferrari G. The role of transcranial Doppler ultrasonography in differential diagnosis of vertigo in the Emergency Department. ECJ 2019; 15(3): 92-6.
[http://dx.doi.org/10.4081/ecj.2019.8341]
[11]
Demarin V, Kes VB, Morović S, Zavoreo I. Evaluation of aging vs dementia by means of neurosonology. J Neurol Sci 2009; 283(1-2): 9-12.
[http://dx.doi.org/10.1016/j.jns.2009.02.006] [PMID: 19268305]
[12]
Foerstl H, Biedert S, Hewer W. Multiinfarct and Alzheimer-type dementia investigated by transcranial Doppler sonography. Biol Psychiatry 1989; 26(6): 590-4.
[http://dx.doi.org/10.1016/0006-3223(89)90084-X] [PMID: 2790097]
[13]
Topcuoglu MA. Transcranial Doppler ultrasound in neurovascular diseases: diagnostic and therapeutic aspects. J Neurochem 2012; 123(Suppl. 2): 39-51.
[http://dx.doi.org/10.1111/j.1471-4159.2012.07942.x] [PMID: 23050641]
[14]
Siniscalchi A, Gallelli L, Iannacchero R. O053. Interictal cerebral posterior circulation in migraineurs with aura: a trancranial color-coded duplexsonography pilot study. J Headache Pain 2015; 16(Suppl. 1): A159.
[http://dx.doi.org/10.1186/1129-2377-16-S1-A159] [PMID: 28132229]
[15]
Malferrari G, Pulito G, Pizzini AM, et al. MicroV technology to improve transcranial color coded Doppler examinations. J Neuroimaging 2018; 28(4): 350-8.
[http://dx.doi.org/10.1111/jon.12517] [PMID: 29727515]
[16]
Panerai RB, White RP, Markus HS, Evans DH. Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure. Stroke 1998; 29(11): 2341-6.
[http://dx.doi.org/10.1161/01.STR.29.11.2341] [PMID: 9804645]
[17]
Malferrari G, Bertolino C, Casoni F, et al. Eligible Group; SINV Group. The Eligible study: ultrasound assessment in acute ischemic stroke within 3 hours. Cerebrovasc Dis 2007; 24(5): 469-76.
[http://dx.doi.org/10.1159/000108922] [PMID: 17895622]
[18]
Blanco P, Abdo-Cuza A. Transcranial Doppler ultrasound in neurocritical care. J Ultrasound 2018; 21(1): 1-16.
[http://dx.doi.org/10.1007/s40477-018-0282-9] [PMID: 29429015]
[19]
Martin PJ, Evans DH, Naylor AR. Measurement of blood flow velocity in the basal cerebral circulation: advantages of transcranial color-coded sonography over conventional transcranial Doppler. J Clin Ultrasound 1995; 23(1): 21-6.
[http://dx.doi.org/10.1002/jcu.1870230105] [PMID: 7699089]
[20]
Malojcic B, Giannakopoulos P, Sorond FA, et al. Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease. BMC Med 2017; 15(1): 27.
[http://dx.doi.org/10.1186/s12916-017-0799-3] [PMID: 28178960]
[21]
Caamaño J, Gómez MJ, Cacabelos R. Transcranial Doppler ultrasonography in senile dementia: neuropsychological correlations. Methods Find Exp Clin Pharmacol 1993; 15(3): 193-9.
[PMID: 8332036]
[22]
Gao YZ, Zhang JJ, Liu H, Wu GY, Xiong L, Shu M. Regional cerebral blood flow and cerebrovascular reactivity in Alzheimer’s disease and vascular dementia assessed by arterial spinlabeling magnetic resonance imaging. Curr Neurovasc Res 2013; 10(1): 49-53.
[http://dx.doi.org/10.2174/156720213804806016] [PMID: 23151075]
[23]
Tsivgoulis G, Katsanos AH, Papageorgiou SG, Dardiotis E, Voumvourakis K, Giannopoulos S. The role of neurosonology in the diagnosis of vascular dementia. J Alzheimers Dis 2014; 42(Suppl. 3): S251-7.
[http://dx.doi.org/10.3233/JAD-132441] [PMID: 24685627]
[24]
Doepp F, Valdueza JM, Schreiber SJ. Transcranial and extracranial ultrasound assessment of cerebral hemodynamics in vascular and Alzheimer’s dementia. Neurol Res 2006; 28(6): 645-9.
[http://dx.doi.org/10.1179/016164106X130380] [PMID: 16945217]
[25]
Kong XD, Zhang Y, Liu L, Sun N, Zhang MY, Zhang JN. Endothelial progenitor cells with Alzheimer’s disease. Chin Med J (Engl) 2011; 124(6): 901-6.
[PMID: 21518600]
[26]
Puglisi V, Bramanti A, Lanza G, Cantone M, Vinciguerra L, Pennisi M, et al. Impaired cerebral haemodynamics in vascular depression: insights from transcranial doppler ultrasonography Front Psychiatry 2018.
[27]
Vicenzini E, Ricciardi MC, Altieri M, et al. Cerebrovascular reactivity in degenerative and vascular dementia: a transcranial Doppler study. Eur Neurol 2007; 58(2): 84-9.
[http://dx.doi.org/10.1159/000103642] [PMID: 17565221]
[28]
Sabayan B, Jansen S, Oleksik AM, et al. Cerebrovascular hemodynamics in Alzheimer’s disease and vascular dementia: a meta-analysis of transcranial Doppler studies. Ageing Res Rev 2012; 11(2): 271-7.
[http://dx.doi.org/10.1016/j.arr.2011.12.009] [PMID: 22226802]
[29]
Kidwell CS, el-Saden S, Livshits Z, Martin NA, Glenn TC, Saver JL. Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease. J Neuroimaging 2001; 11(3): 229-35.
[http://dx.doi.org/10.1111/j.1552-6569.2001.tb00039.x] [PMID: 11462287]
[30]
Ghorbani A, Ahmadi MJ, Shemshaki H. The value of transcranial Doppler derived pulsatility index for diagnosing cerebral small-vessel disease. Adv Biomed Res 2015; 4: 54.
[http://dx.doi.org/10.4103/2277-9175.151574] [PMID: 25802823]
[31]
Keage HA, Churches OF, Kohler M, et al. Cerebrovascular function in aging and dementia: a systematic review of transcranial Doppler studies. Dement Geriatr Cogn Disord Extra 2012; 2(1): 258-70.
[http://dx.doi.org/10.1159/000339234] [PMID: 22822408]
[32]
Roher AE, Garami Z, Tyas SL, et al. Transcranial doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer’s disease. Alzheimers Dement 2011; 7(4): 445-55.
[http://dx.doi.org/10.1016/j.jalz.2010.09.002] [PMID: 21388892]
[33]
Stefani A, Sancesario G, Pierantozzi M, et al. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer’s and mixed dementia. J Neurol Sci 2009; 283(1-2): 109-15.
[http://dx.doi.org/10.1016/j.jns.2009.02.343] [PMID: 19278690]
[34]
Bakker SL, de Leeuw FE, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM. Cerebral haemodynamics in the elderly: the rotterdam study. Neuroepidemiology 2004; 23(4): 178-84.
[http://dx.doi.org/10.1159/000078503] [PMID: 15272220]
[35]
Heun R, Knappertz V, Kraemer G. Transcranial Doppler sonography in dementia of Alzheimer type. Dementia 1994; 5(6): 327-33.
[PMID: 7866486]
[36]
Ruitenberg A, den Heijer T, Bakker SL, et al. Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol 2005; 57(6): 789-94.
[http://dx.doi.org/10.1002/ana.20493] [PMID: 15929050]
[37]
Silvestrini M, Paolino I, Vernieri F, et al. Cerebral hemodynamics and cognitive performance in patients with asymptomatic carotid stenosis. Neurology 2009; 72(12): 1062-8.
[http://dx.doi.org/10.1212/01.wnl.0000345015.35520.52] [PMID: 19307539]
[38]
Aguilar-Navarro SG, Mimenza-Alvarado AJ, Corona-Sevilla I, et al. Cerebral vascular reactivity in frail older adults with vascular cognitive impairment Brain Sci 2019; 9(9): 214.
[http://dx.doi.org/10.3390/brainsci9090214]
[39]
Bär KJ, Boettger MK, Seidler N, Mentzel HJ, Terborg C, Sauer H. Influence of galantamine on vasomotor reactivity in Alzheimer’s disease and vascular dementia due to cerebral microangiopathy. Stroke 2007; 38(12): 3186-92.
[http://dx.doi.org/10.1161/STROKEAHA.107.492033] [PMID: 17962592]
[40]
Markus HS, Harrison MJG. Estimation of cerebrovascular reactivity using transcranial Doppler, including the use of breath-holding as the vasodilatory stimulus. Stroke 1992; 23(5): 668-73.
[http://dx.doi.org/10.1161/01.STR.23.5.668] [PMID: 1579964]
[41]
Matteis M, Silvestrini M, Troisi E, Bragoni M, Vernieri F, Caltagirone C. Cerebral hemodynamic patterns during stimuli tasks in multi-infarct and Alzheimer types of dementia. Acta Neurol Scand 1998; 97(6): 374-80.
[http://dx.doi.org/10.1111/j.1600-0404.1998.tb05969.x] [PMID: 9669470]
[42]
Silvestrini M, Pasqualetti P, Baruffaldi R, et al. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 2006; 37(4): 1010-5.
[http://dx.doi.org/10.1161/01.STR.0000206439.62025.97] [PMID: 16497984]
[43]
Likitjaroen Y, Suwanwela NC, Phanthumchinda K. Vasoreactivity induced by acetazolamide in patients with vascular dementia versus Alzheimer’s disease. J Neurol Sci 2009; 283(1-2): 32-5.
[http://dx.doi.org/10.1016/j.jns.2009.02.363] [PMID: 19375084]
[44]
Rosengarten B, Paulsen S, Molnar S, Kaschel R, Gallhofer B, Kaps M. Activation-flow coupling differentiates between vascular and Alzheimer type of dementia. J Neurol Sci 2007; 257(1-2): 149-54.
[http://dx.doi.org/10.1016/j.jns.2007.01.032] [PMID: 17321550]
[45]
Asil T, Uzuner N. Differentiation of vascular dementia and Alzheimer disease: a functional transcranial Doppler ultrasonographic study. J Ultrasound Med 2005; 24(8): 1065-70.
[http://dx.doi.org/10.7863/jum.2005.24.8.1065] [PMID: 16040820]
[46]
Purandare N, Burns A. Cerebral emboli in the genesis of dementia. J Neurol Sci 2009; 283(1-2): 17-20.
[http://dx.doi.org/10.1016/j.jns.2009.02.306] [PMID: 19249797]
[47]
Purandare N, Burns A, Daly KJ, et al. Cerebral emboli as a potential cause of Alzheimer’s disease and vascular dementia: case-control study. BMJ 2006; 332(7550): 1119-24.
[http://dx.doi.org/10.1136/bmj.38814.696493.AE] [PMID: 16648133]
[48]
Purandare N, Burns A, Morris J, Perry EP, Wren J, McCollum C. Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer’s disease and vascular dementia. Am J Psychiatry 2012; 169(3): 300-8.
[http://dx.doi.org/10.1176/appi.ajp.2011.11010009] [PMID: 22193532]
[49]
Ries F, Horn R, Hillekamp J, Honisch C, König M, Solymosi L. Differentiation of multi-infarct and Alzheimer dementia by intracranial hemodynamic parameters. Stroke 1993; 24(2): 228-35.
[http://dx.doi.org/10.1161/01.STR.24.2.228] [PMID: 8421824]
[50]
O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE. Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 2002; 15(5): 426-44.
[http://dx.doi.org/10.1016/S0895-7061(01)02319-6] [PMID: 12022246]
[51]
Meinders JM, Brands P, Willigers JM, Kornet L, Hoeks AP. Evaluation of spatial homogeneity of artery size parameters with frame rate in B 2-D mode. Ultrasound Med Biol 2001; 27(6): 785-94.
[http://dx.doi.org/10.1016/S0301-5629(01)00351-9] [PMID: 11516538]
[52]
Meinders JM, Hoeks AP. Simultaneous evaluation of pressure diameter and waveforms in the carotid artery. Ultrasound Med Biol Ultrasound 2004; 30: 147-54.
[http://dx.doi.org/10.1016/j.ultrasmedbio.2003.10.014] [PMID: 14998666]
[53]
Reesink KD, Hermeling E, Hoebrigs MC. Characteristics of carotid artery pulse wave time to quantify the ventriculoarterial responses to the orthostatic challenge. J Appl Physiol 2007; 102: 2128-34.
[http://dx.doi.org/10.1152/japplphysiol.01206.2006] [PMID: 17317873]
[54]
Xu Y, Wang Q, Liu Y, Cui R, Lu K, Zhao Y. Association between Helicobacter pylori infection and carotid atherosclerosis in patients with vascular dementia. J Neurol Sci 2016; 362: 73-7.
[http://dx.doi.org/10.1016/j.jns.2016.01.025] [PMID: 26944122]
[55]
Voshaar RC, Purandare N, Hardicre J, McCollum C, Burns A. Asymptomatic spontaneous cerebral emboli and cognitive decline in a cohort of older people: a prospective study. Int J Geriatr Psychiatry 2007; 22(8): 794-800.
[http://dx.doi.org/10.1002/gps.1744] [PMID: 17192026]

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