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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Review Article

A Review on Hepatoprotective Effects of Some Medicinal Plant Oils

Author(s): Nour Elhouda Daoudi, Mohamed Bouhrim and Mohamed Bnouham*

Volume 18, Issue 3, 2021

Published on: 31 August, 2020

Page: [239 - 248] Pages: 10

DOI: 10.2174/1570180817666200831175139

Price: $65

Abstract

Background: The liver is the second largest organ inside the human body. It can be damaged by several toxic molecules and medicinal agents taken in overdoses. Indeed, there are some oils obtained from different herbs that can be used to protect the liver injury.

Objective: This review aims to give details on some oils that have been tested for their hepatoprotective effect.

Methods: We reviewed 79 articles published between 1980 and 2019 in English language using three databases Sciencedirect, Web of Science and PubMed. So, we have used the keywords related to hepatoprotective activity: Hepatoprotective, liver disease, plant and oil and we have classified the plants in alphabetical order as a list containing their scientific and family names, as well as the experimental assay and the results obtained from these studies.

Results: As a result, we have described 18 species belonging to 18 families: Altingiaceae, Apiaceae, Arecaceae, Asteraceae, Cactaceae, Caryocaraceae, Cucurbitaceae, Lauraceae, Leguminoseae, Malvaceae, Moringaceae, Myrtaceae, Oleaceae, Pinaceae, Ranunculaceae, Rosaceae, Theaceae and Vitaceae. Among the most common fatty acids present in hepatoprotective oils are palmitic acid, linoleic acid, oleic acid and stearic acid.

Conclusion: These oils have shown beneficial properties regarding the hepatoprotective activity.

Keywords: Hepatoprotective effect, oils, plants, hepatotoxic agents, carbon tetrachloride, phytotherapy.

Graphical Abstract

[1]
Kandimalla, R.; Kalita, S.; Saikia, B.; Choudhury, B.; Singh, Y.P.; Kalita, K.; Dash, S.; Kotoky, J. Antioxidant and hepatoprotective potentiality of Randia dumetorum Lam. leaf and bark via inhibition of oxidative stress and inflammatory cytokines. Front. Pharmacol., 2016, 7(JUL), 205.
[http://dx.doi.org/10.3389/fphar.2016.00205] [PMID: 27471465]
[2]
Powell, J. Skin physiology. Women’s Heal Med., 2006, 3(3), 130-133.
[http://dx.doi.org/10.1383/wohm.2006.3.3.130]
[3]
Govind, P. Medicinal plants against liver diseases. Int. Res. J. Pharm., 2011, 2(5), 115-121.
[4]
Kumar, C.H.; Ramesh, A.; Kumar, J.N.S.; Ishaq, B.M. A review on hepatoprotective activity of medicinal plants. Int. J. Pharm. Sci. Res., 2011, 2(3), 501-515.
[5]
Domenicali, M.; Caraceni, P.; Giannone, F.; Baldassarre, M.; Lucchetti, G.; Quarta, C.; Patti, C.; Catani, L.; Nanni, C.; Lemoli, R.M.; Bernardi, M. A novel model of CCl4-induced cirrhosis with ascites in the mouse. J. Hepatol., 2009, 51(6), 991-999.
[http://dx.doi.org/10.1016/j.jhep.2009.09.008] [PMID: 19853952]
[6]
Ahmadieh, H.; Azar, S.T. Liver disease and diabetes: Association, pathophysiology, and management. Diabetes Res. Clin. Pract., 2014, 104(1), 53-62.
[http://dx.doi.org/10.1016/j.diabres.2014.01.003] [PMID: 24485856]
[7]
Garcia-Compean, D.; Jaquez-Quintana, J.O.; Gonzalez-Gonzalez, J.A.; Maldonado-Garza, H. Liver cirrhosis and diabetes: risk factors, pathophysiology, clinical implications and management. World J. Gastroenterol., 2009, 15(3), 280-288.
[http://dx.doi.org/10.3748/wjg.15.280] [PMID: 19140227]
[8]
Reddy, V.; Sankar, J.; Rao, G.D.; Mallikajuna, K. A review on anxiolytic activity of some herbal plants. Int. J. Innov. Pharm. Res., 2014, 5(2), 395-404.
[9]
Falzon, CC; Balabanova, A Phytotherapy: An introduction to herbal medicine. Prim Care – Clin. Off. Pract., 2017, 44(2), 217-227.
[10]
Chiu, H-W.; Hua, K-F. Hepatoprotective effect of wheat-based solid-state fermented Antrodia cinnamomea in carbon tetrachloride-induced liver injury in rat. PLoS One, 2016, 11(4),e0153087.
[http://dx.doi.org/10.1371/journal.pone.0153087] [PMID: 27046059]
[11]
Zhao, Q.; Peng, Y.; Huang, K.; Lei, Y.; Liu, H-L.; Tao, Y-Y. Salvianolate protects hepatocytes from oxidative stress by attenuating mitochondrial injury. Evid. Based Compl. Altern. Med., 2016. Article Id 5408075
[http://dx.doi.org/10.1155/2016/5408705]
[12]
Cheng, Y-T.; Lu, C-C.; Yen, G-C. Beneficial effects of camellia oil (Camellia oleifera Abel.) on hepatoprotective and gastroprotective activities. J. Nutr. Sci. Vitaminol. (Tokyo), 2015, 61(Suppl.), S100-S102.
[http://dx.doi.org/10.3177/jnsv.61.S100] [PMID: 26598814]
[13]
Jin, X.; Ning, Y. Antioxidant and antitumor activities of the polysaccharide from seed cake of Camellia oleifera Abel. Int. J. Biol. Macromol., 2012, 51(4), 364-368.
[http://dx.doi.org/10.1016/j.ijbiomac.2012.05.033] [PMID: 22683896]
[14]
Ye, Y.; Guo, Y.; Luo, Y.T.; Wang, Y.F. Isolation and free radical scavenging activities of a novel biflavonoid from the shells of Camellia oleifera Abel. Fitoterapia, 2012, 83(8), 1585-1589.
[http://dx.doi.org/10.1016/j.fitote.2012.09.006] [PMID: 22982330]
[15]
Lee, C.P.; Shih, P.H.; Hsu, C.L.; Yen, G.C. Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem. Toxicol., 2007, 45(6), 888-895.
[http://dx.doi.org/10.1016/j.fct.2006.11.007] [PMID: 17188414]
[16]
Jinlin, M.; Hang, Y.; Yukui, R.; Guochen, C.; Naiyan, Z. Fatty acid composition of Camellia oleifera oil. J. Consum. Prot. Food Saf., 2011, 6, 9-12.
[http://dx.doi.org/10.1007/s00003-010-0581-3]
[17]
Saraiva, R.A.; Araruna, M.K.A.; Oliveira, R.C.; Menezes, K.D.P.; Leite, G.O.; Kerntopf, M.R.; Costa, J.G.; Rocha, J.B.; Tomé, A.R.; Campos, A.R.; Menezes, I.R. Topical anti-inflammatory effect of Caryocar coriaceum Wittm. (Caryocaraceae) fruit pulp fixed oil on mice ear edema induced by different irritant agents. J. Ethnopharmacol., 2011, 136(3), 504-510.
[http://dx.doi.org/10.1016/j.jep.2010.07.002] [PMID: 20621180]
[18]
Torres, L.R de O.; Santana, F.C.; Torres-Leal, F.L.; Melo, I.L.; Yoshime, L.T.; Matos-Neto, E.M.; Seelaender, M.C.; Araújo, C.M.; Cogliati, B.; Mancini-Filho, J. Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects. Food Chem. Toxicol., 2016, 97, 205-216.
[http://dx.doi.org/10.1016/j.fct.2016.09.009] [PMID: 27623180]
[19]
Costa, J.G.; Brito, S.A.; Nascimento, E.M.; Botelho, M.A.; Rodrigues, F.F.; Coutinho, H.D. Antibacterial properties of pequi pulp oil (Caryocar coriaceum - WITTM.). Int. J. Food Prop., 2011, 14(2), 411-416.
[http://dx.doi.org/10.1080/10942910903207744]
[20]
DebMandal. M.; Mandal, S. Coconut (Cocos nucifera L.: Arecaceae): In health promotion and disease prevention. Asian Pac. J. Trop. Med., 2011, 4(3), 241-247.
[http://dx.doi.org/10.1016/S1995-7645(11)60078-3] [PMID: 21771462]
[21]
Zakaria, Z.A.; Rofiee, M.S.; Somchit, M.N.; Zuraini, A.; Sulaiman, M.R.; Teh, L.K.; Salleh, M.Z.; Long, K. Hepatoprotective activity of dried- and fermented-processed virgin coconut oil. Evid. Based Complement. Alternat. Med., 2011, 2011,142739.
[http://dx.doi.org/10.1155/2011/142739] [PMID: 21318140]
[22]
Narayanankutty, A.; Illam, S.P.; Raghavamenon, A.C. Health impacts of different edible oils prepared from coconut (Cocos nucifera): A comprehensive review. Trends Food Sci. Technol., 2018, 80, 1-7.
[http://dx.doi.org/10.1016/j.tifs.2018.07.025]
[23]
Mitich, L. Intriguing world of weeds: Wild carrot (Daucus carota L.). Weed Technol., 1996, 10, 455-457.
[http://dx.doi.org/10.1017/S0890037X00040227]
[24]
El, S.N.; Karakaya, S. Radical scavenging and iron-chelating activities of some greens used as traditional dishes in Mediterranean diet. Int. J. Food Sci. Nutr., 2004, 55(1), 67-74.
[http://dx.doi.org/10.1080/09637480310001642501] [PMID: 14630594]
[25]
Shebaby, W.N.; Daher, C.F.; El-Sibai, M.; Bodman-Smith, K.; Mansour, A.; Karam, M.C.; Mroueh, M. Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota). Pharm. Biol., 2015, 53(9), 1285-1294.
[http://dx.doi.org/10.3109/13880209.2014.976349] [PMID: 25856705]
[26]
Özcan, M.M.; Chalchat, J.C. Chemical composition of carrot seeds (Daucus carota L.) cultivated in Turkey: Characterization of the seed oil and essential oil. Grasas Aceites, 2007, 58(4), 359-365.
[27]
Lívia, DLDO; Carvalho, MV; Aguiar, LA Oliveira, GT Use of baru (Brazilian almond) waste from physical extraction of oil to produce flour and cookies. Lebensm. Wiss. Technol., 2015, 60(1), 50-55.
[http://dx.doi.org/10.1016/j.lwt.2014.09.035]
[28]
Reis, M.Á.; Novaes, R.D.; Baggio, S.R.; Viana, A.L.M.; Salles, B.C.C.; Duarte, S.M.D.S.; Rodrigues, M.R.; Paula, F.B.A. Hepatoprotective and antioxidant activities of oil from baru almonds (Dipteryx alata Vog.) in a preclinical model of lipotoxicity and dyslipidemia. Evid. Based Complement. Alternat. Med., 2018, 2018,8376081.
[http://dx.doi.org/10.1155/2018/8376081] [PMID: 30369957]
[29]
Li, L.Y.; Deji, L.M.; Wei, Y.F.; Zhong, G.Y. [Literature data investigation in semem of Herpetospermum pedunculosum] Zhongguo Zhongyao Zazhi, 2005, 30(12), 893-895.
[PMID: 16124602]
[30]
Fang, Q.M.; Zhang, H.; Cao, Y.; Wang, C. Anti-inflammatory and free radical scavenging activities of ethanol extracts of three seeds used as “Bolengguazi”. J. Ethnopharmacol., 2007, 114(1), 61-65.
[http://dx.doi.org/10.1016/j.jep.2007.07.024] [PMID: 17766069]
[31]
Li, G.; Wang, X.Y.; Suo, Y.R.; Wang, H.L. Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats. Saudi Med. J., 2014, 35(9), 981-987.
[PMID: 25228180]
[32]
Singh, P.; Khan, M.; Hailemariam, H. Nutritional and health importance of Hibiscus Sabdariffa: A review and indication for research needs. J Nutr Heal Food Eng., 2017, 6(5), 125-128.
[33]
Al-Okbi, S.Y.; Abdel-Razek, A.G.; Mohammed, S.E.; Ottai, M.E.S. Roselle seed as a potential new source of healthy edible oil. J. Biol. Sci., 2017, 17(6), 267-277.
[http://dx.doi.org/10.3923/jbs.2017.267.277]
[34]
Ali, S.A.E.; Mohamed, A.H.; Mohammed, G.E.E. Fatty acid composition, anti-inflammatory and analgesic activities of Hibiscus sabdariffa Linn. seeds. J. Adv. Vet. Anim. Res., 2014, 1(2), 50-57.
[http://dx.doi.org/10.5455/javar.2014.a13]
[35]
Ali, R.F.M.; El-Anany, A.M. Hypolipidemic and hypocholesterolemic effect of roselle (Hibiscus sabdariffa L.) seeds oil in experimental male rats. J. Oleo Sci., 2017, 66(1), 41-49.
[http://dx.doi.org/10.5650/jos.ess16126] [PMID: 28049927]
[36]
Hussein, M.E.; El Senousy, A.S.; Abd-Elsalam, W.H.; Ahmed, K.A.; El-Askary, H.I.; Mouneir, S.M. Roselle seed oil and its nano-formulation alleviated oxidative stress, activated nrf2 and downregulated m-RNA expression genes of pro-inflammatory cytokines in paracetamol-intoxicated rat model. Rec. Nat. Prod., 2020, 14(1), 1-17.
[http://dx.doi.org/10.25135/rnp.133.19.03.1220]
[37]
Ahmed, W.K.A.; Hudson, J.F.B. The fatty acid composition of Hibiscus sabdariffa seed oil. J. Sci. Food Agric., 1982, 33, 1305-1309.
[http://dx.doi.org/10.1002/jsfa.2740331217]
[38]
Gurbuz, I.; Yesilada, E.; Demirci, B.; Sezik, E.; Demirci, F.; Baser, K.H.C. Characterization of volatiles and anti-ulcerogenic effect of Turkish sweetgum balsam (Styrax liquidus). J. Ethnopharmacol., 2013, 148(1), 332-336.
[http://dx.doi.org/10.1016/j.jep.2013.03.071] [PMID: 23588094]
[39]
Sağdiç, O.; Özkan, G.; Özcan, M.; Ozçelik, S. A study on inhibitory effects of Siğla tree (Liquidambar orientalis Mill. var. orientalis) storax against several bacteria. Phytother. Res., 2005, 19(6), 549-551.
[http://dx.doi.org/10.1002/ptr.1654] [PMID: 16114094]
[40]
Topal, U.; Sasaki, M.; Goto, M.; Otles, S. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. Int. J. Food Sci. Nutr., 2008, 59(7-8), 619-634.
[http://dx.doi.org/10.1080/09637480701553816] [PMID: 19382349]
[41]
Jeon, S.; Bose, S.; Hur, J.; Jun, K.; Kim, Y.K.; Cho, K.S.; Koo, B.S. A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer’s disease. J. Ethnopharmacol., 2011, 137(1), 783-789.
[http://dx.doi.org/10.1016/j.jep.2011.06.046] [PMID: 21762767]
[42]
Altop, A.; Erener, G.; Duru, M.E.; Isik, K. Effects of essential oils from Liquidambar orientalis Mill. leaves on growth performance, carcass and some organ traits, some blood metabolites and intestinal microbiota in broilers. Br. Poult. Sci., 2018, 59(1), 121-127.
[http://dx.doi.org/10.1080/00071668.2017.1400657] [PMID: 29094608]
[43]
Suzek, H.; Celik, I.; Dogan, A.; Yildirim, S. Protective effect and antioxidant role of sweetgum (Liquidambar orientalis) oil against carbon tetrachloride-induced hepatotoxicity and oxidative stress in rats. Pharm. Biol., 2016, 54(3), 451-457.
[http://dx.doi.org/10.3109/13880209.2015.1045086] [PMID: 26079853]
[44]
Okuda, T.; Baes, A.U.; Nishijima, W.; Okada, M. Isolation and characterization of coagulant extracted from Moringa oleifera seed by salt solution. Water Res., 2001, 35(2), 405-410.
[http://dx.doi.org/10.1016/S0043-1354(00)00290-6] [PMID: 11228992]
[45]
Al-Said, M.S.; Mothana, R.A.; Al-Yahya, M.A.; Al-Blowi, A.S.; Al-Sohaibani, M.; Ahmed, A.F.; Rafatullah, S. Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats. J. Food Sci., 2012, 77(7), T124-T130.
[http://dx.doi.org/10.1111/j.1750-3841.2012.02698.x] [PMID: 22757719]
[46]
Abdulkarim, S.; Long, K.; Lai, O.; Muhammad, S.; Ghazali, H. Frying quality and stability of high-oleic Moringa oleifera seed oil in comparison with other vegetable oils. Food Chem., 2007, 105(4), 1382-1389.
[http://dx.doi.org/10.1016/j.foodchem.2007.05.013]
[47]
Bukhari, M.H.; Khalil, J.; Qamar, S.; Qamar, Z.; Zahid, M.; Ansari, N.; Bakhshi, I.M. Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats. J. Coll. Physicians Surg. Pak., 2011, 21(3), 151-156.
[PMID: 21419021]
[48]
Islam, M.H.; Ahmad, I.Z.; Salman, M.T.; Salman, M.T. Neuroprotective effects of Nigella sativa extracts during germination on central nervous system. Pharmacogn. Mag., 2015, 11(Suppl. 1), S182-S189.
[http://dx.doi.org/10.4103/0973-1296.157729] [PMID: 26109765]
[49]
Al-shdefat, R.I.; Abd-elaziz, M.A.; Al-saikhan, F.I. Genoprotective and genotoxic effects of thymoquinone on doxorubicin-induced damage in Iisolated human leukocytes. Trop. J. Pharm. Res., 2014, 13(12), 2015-2020.
[http://dx.doi.org/10.4314/tjpr.v13i12.10]
[50]
Saleem, U.; Ahmad, B.; Rehman, K.; Mahmood, S.; Alam, M.; Erum, A. Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits. Pak. J. Pharm. Sci., 2012, 25(4), 727-730.
[PMID: 23009987]
[51]
Asaduzzaman, M.; Nahar, L.; Rahman, S.M.; Hasan, M.; Khatun, A.; Tamanna, Z. Hypoglycemic and hypolipidemic potential of Nigella sativa L. seed extract in streptozotocin (STZ)-induced diabetic rats. J. Plant Biochem. Physiol., 2015, 3(4), 2-5.
[52]
Majdalawieh, A.F.; Fayyad, M.W. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int. Immunopharmacol., 2015, 28(1), 295-304.
[http://dx.doi.org/10.1016/j.intimp.2015.06.023] [PMID: 26117430]
[53]
Dinagaran, S.; Sridhar, S.; Eganathan, P. Chemical composition and antioxidant activities of black seed oil (Nigella sativa L.). Int. J. Pharm. Sci. Res., 2016, 7(11), 4473-4479.
[54]
Al-Seeni, M.N.; El Rabey, H.A.; Zamzami, M.A.; Alnefayee, A.M. The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats. BMC Complement. Altern. Med., 2016, 16(1), 438.
[http://dx.doi.org/10.1186/s12906-016-1422-4] [PMID: 27814700]
[55]
Hashem, M.A.; Mohamed, W.A.M.; Attia, E.S.M. Assessment of protective potential of Nigella sativa oil against carbendazim- and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity. Environ. Sci. Pollut. Res. Int., 2018, 25(2), 1270-1282.
[http://dx.doi.org/10.1007/s11356-017-0542-9] [PMID: 29086361]
[56]
Fang, H.L.; Lai, J.T.; Lin, W.C. Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver. Clin. Nutr., 2008, 27(6), 900-907.
[http://dx.doi.org/10.1016/j.clnu.2008.08.004] [PMID: 18824281]
[57]
Ozkan, A.; Aboul-Enein, H.Y.; Kulak, M.; Bindak, R. Comparative study on fatty acid composition of olive (Olea europaea L.), with emphasis on phytosterol contents. Biomed. Chromatogr., 2017, 31(8)
[http://dx.doi.org/10.1002/bmc.3933] [PMID: 28078712]
[58]
Ghazi, Z.; Ramdani, M.; Fauconnier, M.L.; El Mahi, B.; Cheikh, R. Fatty acids sterols and vitamin E composition of seed oil of Opuntia ficus Indica and Opuntia dillenii from Morocco. J. Mater. Environ. Sci., 2013, 4(6), 967-972.
[59]
Ghazi, Z.; Ramdani, M.; Tahri, M.; Rmili, R.; Elmsellem, H.; El Mahi, B. Chemical composition and antioxidant activity of seeds oils and fruit juice of Opuntia ficus indica and Opuntia dillenii from Morocco. J. Mater. Environ. Sci., 2015, 6(8), 2321-2327.
[60]
El Hachimi, F.; Hajjaj, G.; Bendriss, A.; Cherrah, Y.; Alaoui, K. Anti-inflammatory activity of seed oils of Opuntia ficus indica L. and Punica Granatum L. from Morocco. World J. Pharm. Res., 2015, 4(1), 284-294.
[61]
Bouhrim, M.; Ouassou, H.; Choukri, M.; Mekhfi, H.; Ziyyat, A.; Legssyer, A. Hepatoprotective effect of Opuntia dillenii seed oil on CCl4 induced acute liver damage in rat. Asian Pac. J. Trop. Biomed., 2018, 8(5), 254-260.
[62]
Ameer, K. Avocado as a major dietary source of antioxidants and its preventive role in neurodegenerative diseases. Adv. Neurobiol., 2016, 12, 337-354.
[63]
Tan, C.X.; Chong, G.H.; Hamzah, H.; Ghazali, H.M. Hypocholesterolaemic and hepatoprotective effects of virgin avocado oil in diet-induced hypercholesterolaemia rats. Int. J. Food Sci. Technol., 2018, 53(12), 2706-2713.
[http://dx.doi.org/10.1111/ijfs.13880]
[64]
Ortiz-Avila, O.; Figueroa-García, M.D.; García-Berumen, C.I.; Calderón-Cortés, E.; Mejía-Barajas, J.A.; Rodriguez-Orozco, A.R.; Mejía-Zepeda, R.; Saavedra-Molina, A.; Cortés-Rojo, C. Avocado oil induces long-term alleviation of oxidative damage in kidney mitochondria from type 2 diabetic rats by improving glutathione status. J. Bioenerg. Biomembr., 2017, 49(2), 205-214.
[http://dx.doi.org/10.1007/s10863-017-9697-9] [PMID: 28214972]
[65]
Salazar, M.J.; El Hafidi, M.; Pastelin, G.; Ramírez-Ortega, M.C.; Sánchez-Mendoza, M.A. Effect of an avocado oil-rich diet over an angiotensin II-induced blood pressure response. J. Ethnopharmacol., 2005, 98(3), 335-338.
[http://dx.doi.org/10.1016/j.jep.2005.01.044] [PMID: 15814269]
[66]
de Oliveira, A.P. Franco, Ede.S.; Rodrigues Barreto, R.; Cordeiro, D.P.; de Melo, R.G.; de Aquino, C.M.; E Silva, A.A.; de Medeiros, P.L.; da Silva, T.G.; Góes, A.J.; Maia, M.B. Effect of semisolid formulation of Persea americana mill (avocado) oil on wound healing in rats. Evid. Based Complement. Alternat. Med., 2013, 2013,472382.
[http://dx.doi.org/10.1155/2013/472382] [PMID: 23573130]
[67]
Furlan, C.P.B.; Valle, S.C.; Ostman, E.; Marostica, J.M.R. Inclusion of Hass avocado-oil improves postprandial metabolic responses to a hypercaloric-hyperlipidic meal in overweight subjects. J. Funct. Foods, 2017, 38, 349-354.
[http://dx.doi.org/10.1016/j.jff.2017.09.019]
[68]
Abbasi, A.M.; Khan, M.A.; Ahmad, M.; Zafar, M.; Jahan, S.; Sultana, S. Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. J. Ethnopharmacol., 2010, 128(2), 322-335.
[http://dx.doi.org/10.1016/j.jep.2010.01.052] [PMID: 20138210]
[69]
Khan, I.; Singh, V.; Chaudhary, A.K. Hepatoprotective activity of Pinus roxburghii Sarg. wood oil against carbon tetrachloride- and ethanol-induced hepatotoxicity. Bangladesh J. Pharmacol., 2012, 7, 94-99.
[http://dx.doi.org/10.3329/bjp.v7i2.10230]
[70]
Salem, M.Z.; Ali, H.M.; Basalah, M.O. Essential oils from wood, bark, and needles of Pinus roxburghii Sarg. from Alexandria, Egypt: Antibacterial and antioxidant activities. BioResources, 2014, 9(4), 7454-7466.
[http://dx.doi.org/10.15376/biores.9.4.7454-7466]
[71]
Pavlovic, A.V.; Papetti, A.; Zagoracc, D.C.D.; Gasic, U.M.; Misic, D.M.; Tesic, Z.L.; Natic, M.M. Phenolics composition of leaf extracts of raspberry and blackberry cultivars grown in Serbia. Ind. Crops Prod., 2016, 87, 304-314.
[http://dx.doi.org/10.1016/j.indcrop.2016.04.052]
[72]
Johansson, A.; Laakso, P.; Kallio, H. Characterization of seed oils of wild, edible Finnish berries. Z. Lebensm. Unters. Forsch., 1997, 204, 300-307.
[http://dx.doi.org/10.1007/s002170050081]
[73]
Oh, H.H.; Hwang, K.T.; Shin, M.K.; Lee, H.K.; Kim, S.Z. Oils in the seeds of caneberries produced in Korea. J. Am. Oil Chem. Soc., 2007, 84(6), 549-555.
[http://dx.doi.org/10.1007/s11746-007-1065-1]
[74]
Teng, H.; Lin, Q.; Li, K.; Yuan, B.; Song, H.; Peng, H.; Yi, L.; Wei, M.C.; Yang, Y.C.; Battino, M.; Cespedes Acuña, C.L.; Chen, L.; Xiao, J. Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. Food Chem. Toxicol., 2017, 110, 418-424.
[http://dx.doi.org/10.1016/j.fct.2017.09.010] [PMID: 28899773]
[75]
Ciocarlan, A.; Dragalin, I.; Aricu, A.; Ciocarlan, N.; Stavarache, C.; Deleanu, M. Chromatographic analysis of Silybum marianum(L.) gaertn. Fatty oil. Chem. J. Mold., 2018, 13(1), 63-68.
[http://dx.doi.org/10.19261/cjm.2018.484]
[76]
Iqbal, Z.; Waheed, A.; Akram, M.; Mahmood, K. Fatty acid composition of the lipid classes of Silybum marianum seed oil. World J. Pharm. Res., 2015, 4(12), 2183-2191.
[77]
Hermenean, A.; Stan, M.; Ardelean, A.; Pilat, L.; Mihali, C.V.; Propescu, C. Antioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil. Open Life Sci., 2015, 10, 225-236.
[http://dx.doi.org/10.1515/biol-2015-0017]
[78]
Gulçin, I.; Elmastas, M.; Aboul-enein, H.Y. Antioxidant activity of clove oil - A powerful antioxidant source. Arab. J. Chem., 2012, 5(4), 489-499.
[http://dx.doi.org/10.1016/j.arabjc.2010.09.016]
[79]
El-Hadary, A.E.; Ramadan Hassanien, M.F. Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Pharm. Biol., 2016, 54(8), 1364-1372.
[http://dx.doi.org/10.3109/13880209.2015.1078381] [PMID: 26440388]
[80]
Ramadan, M.F. Healthy blends of high linoleic sunflower oil with selected cold pressed oils : Functionality, stability and antioxidative characteristics. Ind. Crops Prod., 2013, 43, 65-72.
[http://dx.doi.org/10.1016/j.indcrop.2012.07.013]
[81]
Ramadan, M.F.; Asker, M.M.S.; Tadros, M. Lipid profile, antiradical power and antimicrobial properties of Syzygium aromaticum oil. Grasas Aceites, 2013, 64(5), 509-520.
[http://dx.doi.org/10.3989/gya.011713]
[82]
Shukri, R.; Mohamed, S.; Mustapha, N.M. Cloves protect the heart, liver and lens of diabetic rats. Food Chem., 2010, 122(4), 1116-1121.
[http://dx.doi.org/10.1016/j.foodchem.2010.03.094]
[83]
Vislocky, L.M.; Fernandez, M.L. Biomedical effects of grape products. Nutr. Rev., 2010, 68(11), 656-670.
[http://dx.doi.org/10.1111/j.1753-4887.2010.00335.x] [PMID: 20961296]
[84]
Rockenbach, I.I.; Jungfer, E.; Ritter, C.; Santiago-schübel, B.; Thiele, B.; Fett, R. Characterization of flavan-3-ols in seeds of grape pomace by CE, HPLC-DAD-MSn and LC-ESI-FTICR-MS. Food Res. Int., 2012, 48(2), 848-855.
[http://dx.doi.org/10.1016/j.foodres.2012.07.001]
[85]
Fernández-mar, M.I.; Mateos, R.; García-parrilla, M.C.; Puertas, B.; Cantos-villar, E. Bioactive compounds in wine: Resveratrol, hydroxytyrosol and melatonin: A review. Food Chem., 2012, 130(4), 797-813.
[http://dx.doi.org/10.1016/j.foodchem.2011.08.023]
[86]
Tangolar, S.G.; Ozoğul, Y.; Tangolar, S.; Torun, A. Evaluation of fatty acid profiles and mineral content of grape seed oil of some grape genotypes. Int. J. Food Sci. Nutr., 2009, 60(1), 32-39.
[http://dx.doi.org/10.1080/09637480701581551] [PMID: 17886077]
[87]
Ismail, A.F.M.; Salem, A.A.M.; Eassawy, M.M.T. Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat. J. Photochem. Photobiol. B, 2016, 160, 1-10.
[http://dx.doi.org/10.1016/j.jphotobiol.2016.03.027] [PMID: 27085796]
[88]
Björnsson, E.S. Hepatotoxicity by drugs: The most common implicated agents. Int. J. Mol. Sci., 2016, 17(2), 224.
[http://dx.doi.org/10.3390/ijms17020224] [PMID: 26861310]
[89]
Czaja, J.; Hepatotoxins, M. Encyclopedia of Gastroenterology; , 2004, pp. 365-367.
[http://dx.doi.org/10.1016/B0-12-386860-2/00367-1]
[90]
Marini-Bettòlo, G.B. Present aspects of the use of plants in traditional medicine. J. Ethnopharmacol., 1980, 2(1), 5-7.
[http://dx.doi.org/10.1016/0378-8741(80)90021-5] [PMID: 7464184]
[91]
Kumar, A.; Sharma, A.; Upadhyaya, K.C. Vegetable oil: Nutritional and industrial perspective. Curr. Genomics, 2016, 17(3), 230-240.
[http://dx.doi.org/10.2174/1389202917666160202220107] [PMID: 27252590]
[92]
Tabee, E.; Azadmard-Damirchi, S.; Jagerstad, M.; Dutta, P.C. Effects of α-tocopherol on oxidative stability and phytosterol oxidation during heating in some regular and high-oleic vegetable oils. J. Am. Oil Chem. Soc., 2008, 85, 857-867.
[http://dx.doi.org/10.1007/s11746-008-1274-2]
[93]
Jadeja, R.N.; Devkar, R.V.; Nammi, S. Oxidative stress in liver diseases: Pathogenesis, prevention and therapeutics. Oxid. Med. Cell. Longev., 2017, 2017,8341286.
[http://dx.doi.org/10.1155/2017/8341286] [PMID: 28529677]

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