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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Recent Developments in the Asymmetric Detrifluoroacetylative Reactions of in situ Generated Mono-Fluorinated Enolates

Author(s): Li Wang, Ziyi Li, Jiang Liu, Jianlin Han*, Hiroki Moriwaki and Vadim A. Soloshonok*

Volume 24, Issue 18, 2020

Page: [2181 - 2191] Pages: 11

DOI: 10.2174/1385272824999200801022712

Price: $65

Abstract

The development of an efficient and mild synthetic methodology for the construction of bioactive fluorine-containing molecules represents one of the hot research topics in general synthetic organic chemistry. In this review, some recent progresses achieved in the development of detrifluoroacetylatively generated mono-fluorinated enolates via CC bond cleavage and their asymmetric nucleophilic reactions for assembly of chiral quaternary C-F center containing compounds.

Keywords: Detrifluoroacetylative reactions, C-F quaternary stereogenic centers, tertiary enolates, asymmetric synthesis, C-C bond cleavage, bioactive compounds.

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