Abstract
Binuclear metal complexes provide an intriguing class of compounds considering both their role in molecular recognition and in catalysis. This review highlights recent developments for the selective recognition of phosphate monoester dianions as diagnostic agents for DNA bulged sequences. The molecular recognition, hydrolysis and oxidation of double-stranded DNA by dinuclear metal complexes are highlighed focusing on recent developments that may lead to new antitumor agents. Additionally, investigations on the allosterism generated by weak host-guest interactions between metalcontaining hosts and metal-containing guests are discussed, and the use of dinuclear copper(II) complexes as tool for selective carbohydrate recognition is emphasized.
Keywords: phosphorylation, Protein tyrosine phosphatases, DNA model, HPNPP cleavage, Oxidation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
3