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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

MALAT1作为癌症的多功能调节剂：从竞争性内源RNA的掠食性作用到机制洞察的更新概述

卷 21, 期 3, 2021

发表于: 30 July, 2020

页: [192 - 202] 页: 11

弟呕挨: 10.2174/1568009620999200730183110

价格: $65

摘要

分子生物学的中心教条一直是经典分子生物学的基石。然而，在线虫中偶然发现的microRNA（miRNA）范例地转移了我们目前对从转录到翻译的过渡过程中复杂机制的认识。 miRNA的发现引起了极大的关注和赞赏，我们目睹了非编码RNA领域的爆炸式增长。非编码RNA领域的突破性发现有助于更好地表征microRNA和长的非编码RNA（LncRNA）。越来越多的miRNA靶标受到MALAT1的调控，以刺激或抑制靶标基因的表达。但是，在这篇综述中，我们的主要重点是总结关于MALAT1介导的致癌信号通路调控的机制。我们已经讨论了MALAT1如何调节各种癌症中的TGF / SMAD和Hippo途径。我们还全面总结了JAK / STAT和Wnt /β-catenin途径如何刺激MALAT1表达，以及因此MALAT1如何增强这些信号传导级联以促进癌症。 MALAT1研究已得到实质性扩展。但是，仍然需要确定其他机制。 MALAT1参与了多个转导级联的多层调节，对不同途径的详细分析将有利于进一步发展个体化药物。

关键词: LncRNA，癌症，凋亡，信号传导，级联，miRNA。

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图形摘要

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