Login Register Cart 0
Generic placeholder image

Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Research Article

Efficacy of Thiol Disulfide Homeostasis and Ischemia Modified Albumin Values in Estimating the Degree of Difficulty for Laparoscopic Cholecystectomy

Author(s): Gökhan Akkurt*, Burcu Akkurt, Emel Alptekın, Birkan Birben, Mehmet Keşkek and Özcan Erel

Volume 24, Issue 3, 2021

Published on: 09 July, 2020

Page: [433 - 440] Pages: 8

DOI: 10.2174/1386207323666200709165910

Price: $65

Abstract

Aim: The aim of this study was to investigate the efficacy of thiol disulfide homeostasis and Ischemia Modified Albumin (IMA) values in predicting the technical difficulties that might be encountered during laparoscopic cholecystectomy.

Materials and Methods: The study included 65 patients who underwent laparoscopic cholecystectomy due to cholelithiasis at the General Surgery Clinic of Ankara Numune Training and Research Hospital. All patients’ demographic data, previous history of cholecystitis, a history of chronic illness, preoperative white blood count (WBC), liver function tests (AST, ALT), amylase and lipase levels, intra-operative adhesion score, the ultrasonographic appearance of gall bladder, duration of hospital stay, duration of operation, thiol disulfide and IMA values were evaluated.

Results: Native thiol and total thiol averages were higher in patients without a history of cholecystitis, and on the other hand, disulfide, disulfide/native thiol rate, disulfide/total thiol rate, native thiol/total thiol rate and IMA averages were higher in patients with a history of cholecystitis. While there was a statistically significant negative correlation between native and total thiol values and age, duration of surgery and duration of hospital stay; IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol rates were higher in older patients with a longer duration of surgery and hospital stay. In addition, preoperative IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol were observed to increase as the degree of intraoperative pericholecystic adhesion increased.

Conclusion: We believe that the evaluation of thiol disulfide homeostasis and IMA parameters prior to laparoscopic cholecystectomy can be used as an effective method for predicting intraoperative difficulties.

Keywords: Thiol disulfide homeostasis, ischemia modified albumin, laparoscopic cholecystectomy, gallbladder, colescystitis, adhesion score.

« Previous Next »
[1]
Liu, C.L.; Fan, S.T.; Lai, E.C.; Lo, C.M.; Chu, K.M. Factors affecting conversion of laparoscopic cholecystectomy to open surgery. Arch. Surg., 1996, 131(1), 98-101.
[http://dx.doi.org/10.1001/archsurg.1996.01430130100022] [PMID: 8546587]
[2]
Chong, J.U.; Lee, J.H.; Yoon, Y.C.; Kwon, K.H.; Cho, J.Y.; Kim, S-J.; Kim, J.K.; Kim, S.H.; Choi, S.B.; Kim, K.S. Influencing factors on postoperative hospital stay after laparoscopic cholecystectomy. Korean J. Hepatobiliary Pancreat. Surg., 2016, 20(1), 12-16.
[http://dx.doi.org/10.14701/kjhbps.2016.20.1.12] [PMID: 26925145]
[3]
Bingener-Casey, J.; Richards, M.L.; Strodel, W.E.; Schwesinger, W.H.; Sirinek, K.R. Reasons for conversion from laparoscopic to open cholecystectomy: a 10-year review. J. Gastrointest. Surg., 2002, 6(6), 800-805.
[http://dx.doi.org/10.1016/S1091-255X(02)00064-1] [PMID: 12504217]
[4]
Lipman, J.M.; Claridge, J.A.; Haridas, M.; Martin, M.D.; Yao, D.C.; Grimes, K.L.; Malangoni, M.A. Preoperative findings predict conversion from laparoscopic to open cholecystectomy. Surgery, 2007, 142(4), 556-563.
[http://dx.doi.org/10.1016/j.surg.2007.07.010] [PMID: 17950348]
[5]
Bat, O. The analysis of 146 patients with difficult laparoscopic cholecystectomy. Int. J. Clin. Exp. Med., 2015, 8(9), 16127-16131.
[PMID: 26629124]
[6]
Rattner, D.W.; Ferguson, C.; Warshaw, A.L. Factors associated with successful laparoscopic cholecystectomy for acute cholecystitis. Ann. Surg., 1993, 217(3), 233-236.
[http://dx.doi.org/10.1097/00000658-199303000-00003] [PMID: 8452401]
[7]
Atmaram, D.C.; Lakshman, K. Predictive factors for conversion of laparoscopic cholecystectomy. Indian J. Surg., 2011, 73(6), 423-426.
[http://dx.doi.org/10.1007/s12262-011-0338-y] [PMID: 23204699]
[8]
Erel, O.; Neselioglu, S. A novel and automated assay for thiol/disulphide homeostasis. Clin. Biochem., 2014, 47(18), 326-332.
[http://dx.doi.org/10.1016/j.clinbiochem.2014.09.026] [PMID: 25304913]
[9]
Matteucci, E.; Giampietro, O. Thiol signalling network with an eye to diabetes. Molecules, 2010, 15(12), 8890-8903.
[http://dx.doi.org/10.3390/molecules15128890] [PMID: 21135801]
[10]
Roy, D.; Quiles, J.; Gaze, D.C.; Collinson, P.; Kaski, J.C.; Baxter, G.F. Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin. Heart, 2006, 92(1), 113-114.
[http://dx.doi.org/10.1136/hrt.2004.049643] [PMID: 16365361]
[11]
Ellidag, H.Y.; Bulbuller, N.; Eren, E.; Abusoglu, S.; Akgol, E.; Cetiner, M.; Yılmaz, N. Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver, 2013, 7(6), 675-680.
[http://dx.doi.org/10.5009/gnl.2013.7.6.675] [PMID: 24312708]
[12]
Cakir, M.; Karahan, S.C.; Mentese, A.; Sag, E.; Cobanoglu, U.; Polat, T.B.; Erduran, E. Ischemia-modified albumin levels in children with chronic liver disease. Gut Liver, 2012, 6(1), 92-97.
[http://dx.doi.org/10.5009/gnl.2012.6.1.92] [PMID: 22375177]
[13]
Bhakthavatsala Reddy, C.; Cyriac, C.; Desle, H.B. Role of “Ischemia Modified Albumin” (IMA) in acute coronary syndromes. Indian Heart J., 2014, 66(6), 656-662.
[http://dx.doi.org/10.1016/j.ihj.2014.12.005] [PMID: 25634401]
[14]
Sugrue, M.; Sahebally, S.M.; Ansaloni, L.; Zielinski, M.D. Grading operative findings at laparoscopic cholecystectomy- a new scoring system. World J. Emerg. Surg., 2015, 10, 14.
[http://dx.doi.org/10.1186/s13017-015-0005-x] [PMID: 25870652]
[15]
Díaz-Flores, A.; Cárdenas-Lailson, E.; Cuendis-Velázquez, A.; Rodríguez-Parra, A.; Trejo-Ávila, M.E. C-Reactive Protein as a Predictor of Difficult Laparoscopic Cholecystectomy in Patients with Acute Calculous Cholecystitis: A Multivariate Analysis. J. Laparoendosc. Adv. Surg. Tech. A, 2017, 27(12), 1263-1268.
[http://dx.doi.org/10.1089/lap.2017.0139] [PMID: 28622085]
[16]
Gupta, N.; Ranjan, G.; Arora, M.P.; Goswami, B.; Chaudhary, P.; Kapur, A.; Kumar, R.; Chand, T. Validation of a scoring system to predict difficult laparoscopic cholecystectomy. Int. J. Surg., 2013, 11(9), 1002-1006.
[http://dx.doi.org/10.1016/j.ijsu.2013.05.037] [PMID: 23751733]
[17]
Vivek, M.A.; Augustine, A.J.; Rao, R. A comprehensive predictive scoring method for difficult laparoscopic cholecystectomy. J. Minim. Access Surg., 2014, 10(2), 62-67.
[http://dx.doi.org/10.4103/0972-9941.129947] [PMID: 24761077]
[18]
Bourgouin, S.; Mancini, J.; Monchal, T.; Calvary, R.; Bordes, J.; Balandraud, P. How to predict difficult laparoscopic cholecystectomy? Proposal for a simple preoperative scoring system. Am. J. Surg., 2016, 212(5), 873-881.
[http://dx.doi.org/10.1016/j.amjsurg.2016.04.003] [PMID: 27329073]
[19]
Shinde, J.; Pandit, S. Innovative Approach to a Frozen Calot’s Triangle During Laparoscopic Cholecystectomy. Indian J. Surg., 2015, 77(6), 554-557.
[http://dx.doi.org/10.1007/s12262-015-1354-0] [PMID: 26884672]
[20]
Sanikidze, T.; Chikvaidze, E. Role of the free radicals in mechanisms of gallstone formation: An EPR Study. Radiat. Prot. Dosimetry, 2016, 172(1-3), 317-324.
[http://dx.doi.org/10.1093/rpd/ncw237] [PMID: 27574326]
[21]
Ozyazici, S.; Karateke, F.; Turan, U.; Kuvvetli, A.; Kilavuz, H.; Karakaya, B.; Ozaltun, P.; Alısık, M.; Erel, O. A novel oxidative stress mediator in acute appendicitis: thiol/disulphide homeostasis. Mediators Inflamm., 2016.20166761050
[http://dx.doi.org/10.1155/2016/6761050] [PMID: 27642237]
[22]
Yuksel, M.; Ates, I.; Kaplan, M.; Alışık, M.; Erel, Ö.; Saygılı, F.; Kayaçetin, E. The dynamic thiol/disulphide homeostasis in inflammatory bowel disease and its relation with disease activity and pathogenesis. Int. J. Colorectal Dis., 2016, 31(6), 1229-1231.
[http://dx.doi.org/10.1007/s00384-015-2439-8] [PMID: 26561415]
[23]
Dumlu, E.G.; Tokaç, M.; Bozkurt, B.; Yildirim, M.B.; Ergin, M.; Yalçin, A.; Kiliç, M. Correlation between the serum and tissue levels of oxidative stress markers and the extent of inflammation in acute appendicitis. Clinics (São Paulo), 2014, 69(10), 677-682.
[http://dx.doi.org/10.6061/clinics/2014(10)05] [PMID: 25518019]
[24]
Sbarouni, E.; Georgiadou, P.; Voudris, V. Ischemia modified albumin changes - review and clinical implications. Clin. Chem. Lab. Med., 2011, 49(2), 177-184.
[http://dx.doi.org/10.1515/CCLM.2011.037] [PMID: 21083441]
[25]
Polat, C.; Kahraman, A.; Yilmaz, S.; Koken, T.; Serteser, M.; Akbulut, G.; Arikan, Y.; Dilek, O.N.; Gokce, O. A comparison of the oxidative stress response and antioxidant capacity of open and laparoscopic hernia repairs. J. Laparoendosc. Adv. Surg. Tech. A, 2003, 13(3), 167-173.
[http://dx.doi.org/10.1089/109264203766207681] [PMID: 12855098]

Rights & Permissions Print Cite
Article Metrics
9
1
© 2024 Bentham Science Publishers | Privacy Policy