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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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General Research Article

Using Alendronic Acid Coupled Fluorescently Labelled SM Liposomes as a Vehicle for Bone Targeting

Author(s): Oula P. Medina*, Tuula P. Medina*, Jana Humbert, Bao Qi, Wolfgang Baum, Olga Will, Timo Damm and Claus Glüer

Volume 26, Issue 46, 2020

Page: [6021 - 6027] Pages: 7

DOI: 10.2174/1381612826666200614175905

Price: $65

Abstract

Background: We recently developed a liposomal nanoparticle system that can be used for drug delivery and simultaneously be monitored by optical or photoacoustic imaging devices. Here we tested the efficacy of alendronate as a homing molecule in SM-liposomes for bone targeting.

Methods: Alendronate was immobilized covalently on the liposomal surface and the fluorescent dye indocyanine green was used as a payload in the liposomes. The indocyanine green delivery was analyzed by 3D optical tomography, optical fluorescence scanner, photoacoustic imaging, and by ex-vivo biodistribution studies.

Results: The results show that the alendronate, coupled to the liposomal surface, increases sphingomyelin containing liposome targeting up to several-folds.

Conclusion: The alendronate targeted liposomes open possibilities for an application in active bone targeting.

Keywords: Alendronic acid, liposomes, multimodal imaging, ICG, sphingomyelin, bone targeting.

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