Triethanolammonium Acetate ([TEAH][OAc]) as a Recyclable Promoter and Medium for Green and Four-component Synthesis of Polyfunctionalized Pyrrole Derivatives

Behjat       Pouramiri; Milad       Daneshi; Fatemeh       Seyedi; Najmeh       Amirmahani

doi:10.2174/1570178617999200611150616

Abstract

Multi-component synthesis of functionalized pyrrole derivatives was achieved via a fourcomponent condensation reaction of ethyl acetoacetate/ methyl acetoacetate, aromatic amines, nitromethane, and aromatic aldehydes using triethanolammonium acetate ([TEAH][OAc]) ionic liquid as a green solvent and catalyst. Easy access to highly substituted pyrroles, reusability of the catalyst, broad substrate scopes, no column chromatography, short reaction time, good yields of products and solventfree conditions make this protocol environmentally friendly and practically attractive.

Keywords: Functionalized pyrrole derivatives, multi-component reaction (MCRs), green synthesis, ionic liquid, no column chromatography, solvent-free conditions.

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DOI https://dx.doi.org/10.2174/1570178617999200611150616	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

Letters in Organic Chemistry

Triethanolammonium Acetate ([TEAH][OAc]) as a Recyclable Promoter and Medium for Green and Four-component Synthesis of Polyfunctionalized Pyrrole Derivatives

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