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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats

Author(s): Fadwa El-Ouady and Mohamed Eddouks*

Volume 21, Issue 4, 2021

Published on: 10 June, 2020

Page: [711 - 719] Pages: 9

DOI: 10.2174/1871530320666200610153532

Price: $65

Abstract

Aim: The study was conducted to assess the antidiabetic and antihyperlipidemic effects of Lippia citriodora.

Background: Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.

Objective: The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.

Methods: Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also evaluated. The in vitro antioxidant activity of LCLAE was also assessed.

Results: LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated the liver structure and exhibited antioxidant activity.

Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of LCLAE in rats.

Keywords: Antidiabetic, antihyperlipidemic, Lippia citriodora, histopathology, antioxidant activity, liver, streptozotocin, medicinal plant.

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