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Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Review Article

Liver Cirrhosis Complications Management at the Emergency Department

Author(s): Emidio Scarpellini, Carmelo Luigiano, Gianluca Svegliati-Baroni, Dan Dumitrascu, Tiziana Larussa, Valeria Santori, Francesco Luzza and Ludovico Abenavoli*

Volume 15, Issue 4, 2020

Page: [331 - 338] Pages: 8

DOI: 10.2174/1574887115666200603160816

Price: $65

Abstract

Background and Aims: Liver cirrhosis (LC) of any origin has always been a source of several emergencies for physicians working at the Emergency Department (ER). LC patients can present with several complications that are sometimes difficult to recognize and treat.

Thus, we reviewed the literature evidence for the diagnosis and management of several LC related emergencies.

Methods: We conducted a search on the main medical databases for papers, reviews, metanalyses, case series, and RCTs using the following keywords and their associations: liver cirrhosis, variceal hemorrhage, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepato-renal syndrome, emergency.

Results: Main LC emergencies are upper gastrointestinal hemorrhage, decompensated ascites and spontaneous bacterial peritonitis, hepatic encephalopathy, hepato-renal syndrome. Their management is partly medical and interventional. Very often, the final cure of some complications, such as hepato-renal syndrome, is represented by liver transplantation.

Conclusion: Although LC prevalence is going to fall in the following years, due to HBV and HCV optimized treatments, its complications represent a significant admission percentage at the ER and challenge for physicians’ skills.

Keywords: Liver cirrhosis, variceal hemorrhage, ascites, spontaneous bacterial peritonitis, hepato-renal syndrome, emergency.

Graphical Abstract

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