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Review Article

粪便微生物群移植在炎症性肠病中的应用:当前观念和未来挑战

卷 21, 期 14, 2020

页: [1440 - 1447] 页: 8

弟呕挨: 10.2174/1389450121666200602125507

价格: $65

摘要

在炎症性肠病(IBD)中反复观察到生态失调，现在被认为是肠道炎症过程中的一个重要因素。IBD是卫生保健系统的一个重大负担，主要原因是与治疗有关的费用。现有的治疗有几个限制:高达30%的患者是原发性无反应者，每年有10%到20%的患者失去反应，需要增加剂量或改用另一种生物制剂。因此，目前的IBD治疗是不够的，迫切需要引进新的治疗方法来管理这些患者。最近，纠正生态失调已经成为一个有吸引力的方法，从治疗的观点。粪便菌群移植(FMT)似乎是一种可靠和潜在有益的治疗IBD患者。正在发展的数据表明，FMT对于轻度到中度活跃的UC是一种安全有效的缓解诱导疗法。然而，目前的研究设计不同，随访时间短，这使得临床解释非常困难。有必要使用FMT对CD患者进行明确的队列研究来进行rct治疗。应该考虑到疾病的位置、行为和严重程度。这篇手稿的目的是回顾现有的关于FMT和IBD的数据，解释FMT在IBD患者中的原理和方法，并讨论一些尚未解决的问题。

关键词: 克罗恩病，炎症性肠病，粪便菌群移植，肠道菌群，溃疡性结肠炎，生态失调

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