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ISSN (Online): 2212-4020

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Review Article

Plant-Derived Butters as Lipid Nanocarriers: A Systematic and Prospective Review

Author(s): Angélica G. Coelho, Webysten R.P. dos Santos, Andressa A. dos Santos, Maisa G. da Silva, Francisco V. Macedo Cunha, Anderson N. Mendes and Daniel D.R. Arcanjo*

Volume 14, Issue 4, 2020

Page: [262 - 275] Pages: 14

DOI: 10.2174/1872210514666200522213144

Price: $65

Abstract

Background: Pharmaceutical nanotechnology represents an efficient alternative for the delivery of pharmacologically active plant-derived compounds, considering their protective capacity, oral bioavailability and drug vectorization capacity. In this context, butters obtained from plant seeds have emerged as promising products for the development of pharmacologically active nanostructures. They possess a complex lipid composition, allowing the formation of different emulsion systems with solid cores, since this mixture of different triglycerides is solid at room temperature and body temperature. Therefore, the systematic mapping around the technological development of nanostructures produced from plant-derived butters is potentially valuable for researchers interested in novel alternative formulations for pharmacological therapy, with potential industrial, economic, health and societal impacts.

Methods: Systematic review was carried out by the search of scientific papers and patents deposited in official databases concerning the development of nanostructured pharmaceutical products using plantderived butters as starting material. The publications obtained were subjected to sorting and analysis by applying the following inclusion/exclusion criteria.

Results: The Solid Lipid Nanoparticle (SLN) was the type of nanostructure produced in all the analyzed scientific papers, due to the physicochemical characteristics of the lipid constituents of plantderived butters. In this sense, 54% of the articles have reported the use of Cocoa Butter for the production of nanostructures; 28% for Shea Butter; 6% for Cupuacu Butter, 6% for Murumuru Butter and 6% for Bacuri Butter.

Discussion: In the technological prospection, only two patents exhibited SLN as an invention based on cocoa butter and on shea butter, respectively. The production methods employed have included: phase inversion temperature, microemulsion, hot high pressure homogenization, high shear homogenization and ultrasonication.

Conclusion: In light of this prospective review, the encouragement of novel studies in lipids-based nanotechnology is evident, considering the small number of findings so far, in order to stimulate new research involving plant-derived butters from easily cultivated fruits in tropical regions, then stimulating the pharmaceutical development of new therapeutic alternatives using biocompatible and sustainable raw materials.

Keywords: Biotechnology, nanoparticles, nanotechnology, plant-derived butter, scientific prospection, technological prospection.

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[1]
Akhoond ZA, Mohebbi M, Farhoosh R, Bolurian S. Production and characterization of nanostructured lipid carriers and solid lipid nanoparticles containing lycopene for food fortification. J Food Sci Technol 2018; 55(1): 287-98.
[http://dx.doi.org/10.1007/s13197-017-2937-5] [PMID: 29358821]
[2]
Prakash M, Basavaraj BV, Murthy KNC. Biological functions of epicatechin: Plant cell to human cell health. J Funct Foods 2019; 52: 14-24.
[http://dx.doi.org/10.1016/j.jff.2018.10.021]
[3]
Sadegh Malvajerd S, Azadi A, Izadi Z, et al. Brain delivery of curcumin using solid lipid nanoparticles and nanostructured lipid carriers: Preparation, optimization, and pharmacokinetic evaluation. ACS Chem Neurosci 2019; 10(1): 728-39.
[http://dx.doi.org/10.1021/acschemneuro.8b00510] [PMID: 30335941]
[4]
Ding Y, Nielsen KA, Nielsen BP, Bøje NW, Müller RH, Pyo SM. Lipid-Drug-Conjugate (LDC) Solid Lipid Nanoparticles (SLN) for the delivery of nicotine to the oral cavity - Optimization of nicotine loading efficiency. Eur J Pharm Biopharm 2018; 128: 10-7.
[http://dx.doi.org/10.1016/j.ejpb.2018.03.004] [PMID: 29545120]
[5]
Jange CG, Ambrose RPK. Effect of surface compositional difference on powder flow properties. Powder Technol 2019; 344: 363-72.
[http://dx.doi.org/10.1016/j.powtec.2018.12.027]
[6]
Fadul JC, Leite CTS, Sousa LS, et al. In vitro evaluation of the antifungal activity of anionic cream and solution incorporated with dried leaf extract of Psidium guajava L. Rev Bras Farm 2018; 99(2): 2520-39.
[7]
Cunha FVM, Coelho AG, Azevedo PSDS, da Silva AA, Oliveira FA, Nunes LCC. Systematic review and technological prospection: Ethyl ferulate, a phenylpropanoid with antioxidant and neuroprotective actions. Expert Opin Ther Pat 2019; 29(2): 73-83.
[http://dx.doi.org/10.1080/13543776.2019.1568410] [PMID: 30681375]
[8]
Rizvi SAA, Saleh AM. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J 2018; 26(1): 64-70.
[http://dx.doi.org/10.1016/j.jsps.2017.10.012] [PMID: 29379334]
[9]
Dias SFL, Pereira LCA, Oliveira AP, Santos RFD, Nunes LCC. Scientific and technological prospection on transdermal formulations and complementary therapies for the treatment of primary dysmenorrhea. Expert Opin Ther Pat 2019; 29(2): 115-26.
[http://dx.doi.org/10.1080/13543776.2019.1562547] [PMID: 30587041]
[10]
Müller RH, Petersen RD, Hommoss A, Pardeike J. Nanostructured Lipid Carriers (NLC) in cosmetic dermal products. Adv Drug Deliv Rev 2007; 59(6): 522-30.
[http://dx.doi.org/10.1016/j.addr.2007.04.012] [PMID: 17602783]
[11]
Ribeiro LNM, Breitkreitz MC, Guilherme VA, et al. Natural lipids-based NLC containing lidocaine: From pre-formulation to in vivo studies. Eur J Pharm Sci 2017; 106: 102-12.
[http://dx.doi.org/10.1016/j.ejps.2017.05.060] [PMID: 28558981]
[12]
Coelho AG, Lima Neto JS, Moura AKS, et al. Pharmaceutical development of tablets containing a spray-dried optimized extract from Lippia origanoides HBK: Influence of excipients and toxicological assessment. Braz J Pharm Sci 2018; 54(2): 1-11.
[http://dx.doi.org/10.1590/s2175-97902018000217226]
[13]
Altamimi MA, Elzayat EM, Qamar W, et al. Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion. Saudi Pharm J 2019; 27(5): 629-36.
[http://dx.doi.org/10.1016/j.jsps.2019.03.004] [PMID: 31297016]
[14]
Mahmoudian M, Valizadeh H, Zakeri-Milani P. Bortezomib-loaded solid lipid nanoparticles: Preparation, characterization, and intestinal permeability investigation. Drug Dev Ind Pharm 2018; 44(10): 1598-605.
[http://dx.doi.org/10.1080/03639045.2018.1483385] [PMID: 29874944]
[15]
Rostami E, Kashanian S, Azandaryani AH, Faramarzi H, Dolatabadi JE, Omidfar K. Drug targeting using solid lipid nanoparticles. Chem Phys Lipids 2014; 181: 56-61.
[http://dx.doi.org/10.1016/j.chemphyslip.2014.03.006] [PMID: 24717692]
[16]
Mehnert W, Mäder K. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 2001; 47(2-3): 165-96.
[http://dx.doi.org/10.1016/S0169-409X(01)00105-3] [PMID: 11311991]
[17]
Callender SP, Mathews JA, Kobernyk K, Wettig SD. Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. Int J Pharm 2017; 526(1-2): 425-42.
[http://dx.doi.org/10.1016/j.ijpharm.2017.05.005] [PMID: 28495500]
[18]
Nur HCM, Roswanira AW, Mariani AH. An overview of nanoemulsion: Concepts of development and cosmeceutical applications. Biotechnol Biotechnol Equip 2019; 33(1): 779-97.
[http://dx.doi.org/10.1080/13102818.2019.1620124]
[19]
Saiwal N, Dahiya M, Dureja H. Recent patents and formulation of nanopharmaceuticals using ultrasonication technique. Recent Pat Nanotechnol 2018; 12(2): 86-100.
[http://dx.doi.org/10.2174/1872210511666171120100649] [PMID: 29165099]
[20]
Gomes GVL, Mirella R, Sola MR, et al. Physico-chemical stability and in vitro digestibility of beta-carotene-loaded lipid nanoparticles of cupuacu butter (Theobroma grandiflorum) produced by the Phase Inversion Temperature (PIT) method. J Food Eng 2017; 192: 93-102.
[http://dx.doi.org/10.1016/j.jfoodeng.2016.08.001]
[21]
Solans C, Solé I. Nano-emulsions: Formation by low-energy methods. Curr Opin Colloid Interface Sci 2017; 17: 246-54.
[http://dx.doi.org/10.1016/j.cocis.2012.07.003]
[22]
Ganesan P, Ramalingam P, Karthivashan G, Ko YT, Choi DK. Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases. Int J Nanomedicine 2018; 13: 1569-83.
[http://dx.doi.org/10.2147/IJN.S155593] [PMID: 29588585]
[23]
Oliveira-júnior RG, Almeida JRGS. Technological exploration of Ananas comosus (Bromeliacea). Rev Geintec 2012; 2(5): 505-13.
[24]
Neves JA, Neves JA, Oliveira RCM. Pharmacological and biotechnological advances with Rosmarinus officinalis L. Expert Opin Ther Pat 2018; 28(5): 399-413.
[http://dx.doi.org/10.1080/13543776.2018.1459570] [PMID: 29633892]
[25]
Müller RH, Mäder K, Gohla S. Solid Lipid Nanoparticles (SLN) for controlled drug delivery - A review of the state of the art. Eur J Pharm Biopharm 2000; 50(1): 161-77.
[http://dx.doi.org/10.1016/S0939-6411(00)00087-4] [PMID: 10840199]
[26]
Sheoran R, Khokra SL, Chawla V, Dureja H. Recent patents, formulation techniques, classification and characterization of liposomes. Recent Pat Nanotechnol 2019; 13(1): 17-27.
[http://dx.doi.org/10.2174/1872210513666181127110413] [PMID: 30479223]
[27]
Rajabi M, Mousa SA. Lipid nanoparticles and their application in nanomedicine. Curr Pharm Biotechnol 2016; 17(8): 662-72.
[http://dx.doi.org/10.2174/1389201017666160415155457] [PMID: 27087491]
[28]
Kaur J, Singh G, Saini S, Rana A. Innovative growth in developing new methods for formulating solid lipid nanoparticles and microparticles. J Drug Deliv Ther 2012; 2(5): 146-50.
[http://dx.doi.org/10.22270/jddt.v2i5.295]
[29]
Geszke-Moritz M, Moritz M. Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies. Mater Sci Eng C 2016; 68: 982-94.
[http://dx.doi.org/10.1016/j.msec.2016.05.119] [PMID: 27524099]
[30]
Soddu E, Rassu G, Cossu M, Giunchedi P, Cerri G, Gavini E. The effect of formulative parameters on the size and physical stability of SLN based on “green” components. Pharm Dev Technol 2016; 21(1): 98-107.
[http://dx.doi.org/10.3109/10837450.2014.971376] [PMID: 25331189]
[31]
Kim BD, Na K, Choi HK. Preparation and characterization of Solid Lipid Nanoparticles (SLN) made of cacao butter and curdlan. Eur J Pharm Sci 2005; 24(2-3): 199-205.
[http://dx.doi.org/10.1016/j.ejps.2004.10.008] [PMID: 15661491]
[32]
Kuo YC, Chung CY. Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir. Colloids Surf B Biointerfaces 2011; 88(2): 682-90.
[http://dx.doi.org/10.1016/j.colsurfb.2011.07.060] [PMID: 21865017]
[33]
Suter F, Schmid D, Wandrey F, Zülli F. Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications. Eur J Pharm Biopharm 2016; 108: 304-9.
[http://dx.doi.org/10.1016/j.ejpb.2016.06.014] [PMID: 27343822]
[34]
Qian C, Decker EA, Xiao H, et al. Impact of lipid nanoparticle physical state on particle aggregation and β-carotene degradation: Potential limitations of solid lipid nanoparticles. Food Res Int 2013; 52(1): 342-9.
[http://dx.doi.org/10.1016/j.foodres.2013.03.035]
[35]
Amekyeh H, Billa N, Yuen KH, Lim SC. Effect of food status on the gastrointestinal transit of amphotericin B-containing solid lipid nanoparticles in rats. AAPS PharmSciTech 2016; 17(5): 1060-6.
[http://dx.doi.org/10.1208/s12249-015-0438-2] [PMID: 26511938]
[36]
Raffin RP, Lima A, Lorenzoni R, et al. Natural lipid nanoparticles containing nimesulide: synthesis, characterization and in vivo antiedematogenic and antinociceptive activities. J Biomed Nanotechnol 2012; 8(2): 309-15.
[http://dx.doi.org/10.1166/jbn.2012.1377] [PMID: 22515082]
[37]
Ali HH, Michaux F, Ntsama ISB, et al. Shea butter solid nanoparticles for curcumin encapsulation: Influence of nanoparticles size on drug loading. Eur J Lipid Sci Technol 2016; 118(8): 1168-78.
[http://dx.doi.org/10.1002/ejlt.201500348]
[38]
Ali HH, Michaux F, Khanji AN, et al. Chitosan -Shea butter solid nanoparticles assemblies for the preparation of a novel nanoparticles in microparticles system containing curcumin. Colloid Surf A Physicochem Eng Asp 2 2018; 553: 359-67.
[39]
Nahr FK, Ghanbarzadeh B, Hamishehkar H, Kafil HS. Food grade nanostructured lipid carrier for cardamom essential oil: Preparation, characterization and antimicrobial activity. J Funct Foods 2018; 40: 1-8.
[http://dx.doi.org/10.1016/j.jff.2017.09.028]
[40]
Saporito F, Sandri G, Bonferoni MC, et al. Essential oil-loaded lipid nanoparticles for wound healing. Int J Nanomedicine 2017; 13: 175-86.
[http://dx.doi.org/10.2147/IJN.S152529] [PMID: 29343956]
[41]
Kuo YC, Wang CC. Cationic solid lipid nanoparticles with cholesterol-mediated surface layer for transporting saquinavir to the brain. Biotechnol Prog 2014; 30(1): 198-206.
[http://dx.doi.org/10.1002/btpr.1834] [PMID: 24167123]
[42]
Shtay R, Tan CP, Schwarz K. Development and characterization of Solid Lipid Nanoparticles (SLNs) made of cocoa butter: A factorial design study. J Food Eng 2018; 231: 30-41.
[http://dx.doi.org/10.1016/j.jfoodeng.2018.03.006]
[43]
Malgarim CL, Faccendini A, Catanzaro M, et al. The role of chitosan as coating material for nanostructured lipid carriers for skin delivery of fucoxanthin. Int J Pharm 2019; 567118487
[http://dx.doi.org/10.1016/j.ijpharm.2019.118487] [PMID: 31271813]
[44]
Gomes GVL, Sola MR, Rochetti AL, Fukumasu H, Vicente AA, Pinho SC. β-carotene and α-tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: Characterisation, dynamic in vitro digestion and cell viability study. J Microencapsul 2019; 36(1): 43-52.
[http://dx.doi.org/10.1080/02652048.2019.1585982] [PMID: 30836027]
[45]
Salvia-Trujillo L, Verkempinck S, Rijal SK, Van Loey A, Grauwet T, Hendrickx M. Lipid nanoparticles with fats or oils containing β-carotene: Storage stability and in vitro digestibility kinetics. Food Chem 2019; 278(25): 396-405.
[http://dx.doi.org/10.1016/j.foodchem.2018.11.039] [PMID: 30583390]
[46]
McClements DJ, Rao J. Food-grade nanoemulsions: Formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr 2011; 51(4): 285-330.
[http://dx.doi.org/10.1080/10408398.2011.559558] [PMID: 21432697]
[47]
Anton N, Vandamme TF. The universality of low-energy nano-emulsification. Int J Pharm 2009; 377(1-2): 142-7.
[http://dx.doi.org/10.1016/j.ijpharm.2009.05.014] [PMID: 19454306]
[48]
Salminen H, Helgason T, Aulbach S, Kristinsson B, Kristbergsson K, Weiss J. Influence of co-surfactants on crystallization and stability of solid lipid nanoparticles. J Colloid Interface Sci 2014; 426: 256-63.
[http://dx.doi.org/10.1016/j.jcis.2014.04.009] [PMID: 24863791]
[49]
Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: Structure, preparation and application. Adv Pharm Bull 2015; 5(3): 305-13.
[http://dx.doi.org/10.15171/apb.2015.043] [PMID: 26504751]
[50]
Neves AR, Lúcio M, Martins S, Lima JLC, Reis S. Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Int J Nanomedicine 2013; 8: 177-87.
[PMID: 23326193]
[51]
Manjunath K, Reddy JS, Venkateswarlu V. Solid lipid nanoparticles as drug delivery systems. Methods Find Exp Clin Pharmacol 2005; 27(2): 127-44.
[http://dx.doi.org/10.1358/mf.2005.27.2.876286] [PMID: 15834465]
[52]
Glaubitt K, Ricci M, Giovagnoli S. Exploring the nano spray-drying technology as an innovative manufacturing method for solid lipid nanoparticle dry powders. AAPS PharmSciTech 2019; 20(1): 19.
[http://dx.doi.org/10.1208/s12249-018-1203-0] [PMID: 30604256]
[53]
Ahmad I, Anwar M, Akhter S, et al. Supercritical fluid technology-based trans-resveratrol SLN for long circulation and improved radioprotection. J Pharm Innov 2016; 11: 308-22.
[http://dx.doi.org/10.1007/s12247-016-9254-9]
[54]
Yanes CVI, Filho AAM, Ribeiro PRE, et al. Inhibition of Acetylcholinesterase and fatty acid composition in Theobroma grandiflorum seeds. Orbital: Electron J Chem 2017; 9(3): 127-30.
[55]
Ugese FD, Baiyeri PK, Mbah BN. Fatty acid profile of Shea tree (Vitellaria paradoxa C. F. Gaertn.) seeds from the Savanna of Nigeria. For Trees Livelihoods 2010; 19(4): 393-8.
[http://dx.doi.org/10.1080/14728028.2010.9752680]
[56]
Kun N, Woo JS, Haeng LD, Ki-Baik H, Hyun-Chul S, Gregory-Jy C. Solid lipid nanoparticles for drug delivery, a process for the preparatrion thereof, and an injection comprising the same. WO Patent 102121A2, 2009..
[57]
Moroz JBA, Silva FL. Adami DSF, et al. A Nanostructured conditioning cosmetic composition, the use thereof in cosmetic preparations,and a conditioning shampoo México. MX20160005413 20141030. 2013..
[58]
Santos WRP. Obtaining solid lipid nanoparticles produced from a bacuri seed butter (Platonia insignis mart.) Monograph presented to the Faculty of Pharmacy, Federal University of Piauí 2018.https://sigaa.ufpi.br/sigaa/verProducao?idProducao=2226041&key=2a9cbf9303790938025e1-2521ea4b06a [Accessed June 2020]
[59]
Attama AA, Schicke BC, Paepenmüller T, Müller-Goymann CC. Solid lipid nanodispersions containing mixed lipid core and a polar heterolipid: Characterization. Eur J Pharm Biopharm 2007; 67(1): 48-57.
[http://dx.doi.org/10.1016/j.ejpb.2006.12.004] [PMID: 17276663]

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