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Case Report

BK Polyoma Virus Nephropathy in an Immunocompromised Host

Author(s): Faraz Khan*, Maroun El Khoury, Fahad Kouli and Aaron Han

Volume 2, Issue 1, 2021

Published on: 20 May, 2020

Page: [45 - 49] Pages: 5

DOI: 10.2174/0250688201999200520125625

open_access

Abstract

Background: Post-transplant Lymphoproliferative Disorders (PTLD) are a well known late complication after solid organ transplantation, including renal transplant. Among others, graft failure due to reactivation of BK polyomavirus in the grafted kidney is also a well-recognized complication but tends to present early in the first several months after transplant.

Case: Here we present the case of PTLD Burkitt's Lymphoma (BL-PTLD) in a renal transplant patient who was successfully treated with multiagent chemo-immunotherapy but later developed BK polyomavirus nephropathy (BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after the transplant. Relevant literature is reviewed.

Conclusion: In this case, reactivation and progression of BKVN were most likely associated with immunosuppression from chemo-immunotherapy for her BL–PTLD, unlike early graft failures associated with BKVN.

Keywords: PTLD, Burkitt's Lymphoma, BK polyomavirus nephropathy, Lymphoproliferative disorders, Immunosuppression, Chemoimmunotherapy.

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