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Review Article

链霉菌铁载体作为新抗生素的生物技术潜力

卷 28, 期 7, 2021

发表于: 10 May, 2020

页: [1407 - 1421] 页: 15

弟呕挨: 10.2174/0929867327666200510235512

价格: $65

摘要

背景：铁载体是由大部分在低铁条件下生长的微生物和植物产生的小分子铁螯合剂。铁载体允许铁捕获并通过细胞膜转运到细胞质中，在那里铁被释放出来用于生物过程。这些细菌铁吸收系统可用于抗生素结合或作为杀死病原细菌的靶标。由于铁载体在环境和治疗研究中的潜在应用，因此最近对其进行了研究。它们存在于革兰氏阳性菌链霉菌中，是发现新铁载体的重要来源。 目的：这篇综述总结了链霉菌属产生的铁载体分子，强调了其作为生物技术生产者的潜力，还阐明了用于发现可用于治疗细菌感染的铁载体的基因组工具。 方法：使用PUBMED和MEDLINE数据库进行文献检索，关键词为铁载体，次生代谢物，特洛伊木马策略，铁霉素和链霉菌。文献研究集中于书目数据库，包括链霉菌属中鉴定的所有铁载体。此外，通过使用antiSMASH平台，将GenBank链霉菌的参考基因组用于鉴定铁载体生物合成基因簇。 结果：这篇综述着重介绍了链霉菌产生的许多铁载体分子，说明了其化学结构的多样性以及对病原菌的广泛生物活性。此外，使用与抗生素偶联的铁载体可能是克服细菌对药物耐药性的替代方法，并可以提高其治疗效果。 结论：这项审查证实了链霉菌作为铁载体的丰富来源的重要性，并强调了其作为抗菌剂的潜力。

关键词: 铁载体，链霉菌，放线菌，铁霉素，细菌感染，“特洛伊木马”方法。

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