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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Advances in the Application of Liposomal Nanosystems in Anticancer Therapy

Author(s): Dexuan Xiao and Ronghui Zhou*

Volume 16, Issue 1, 2021

Published on: 23 April, 2020

Page: [14 - 22] Pages: 9

DOI: 10.2174/1574888X15666200423093906

Price: $65

Abstract

Cancer is the disease with the highest mortality rate, which poses a great threat to people’s lives. Cancer caused approximately 3.4 million death worldwide annually. Surgery, chemotherapy and radiotherapy are the main therapeutic methods in clinical practice. However, surgery is only suitable for patients with early-stage cancers, and chemotherapy as well as radiotherapy have various side effects, both of which limit the application of available therapeutic methods. In 1965, liposome was firstly developed to form new drug delivery systems given the unique properties of nanoparticles, such as enhanced permeability and retention effect. During the last 5 decades, liposome has been widely used for the purpose of anticancer drug delivery, and several advances have been made regarding liposomal technology, including long-circulating liposomes, active targeting liposomes and triggered release liposomes, while problems exist all along. This review introduced the advances as well as the problems during the development of liposomal nanosystems for cancer therapy in recent years.

Keywords: Liposome, cancer, chemotherapy, drug delivery, function improvements, combination therapy.

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