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Review Article

多能干细胞正向神经元编程

卷 21, 期 1, 2021

发表于: 21 April, 2020

页: [5 - 14] 页: 10

弟呕挨: 10.2174/1566524020666200421115251

价格: $65

摘要

多能干细胞（PSC）是研究发育生物学和神经元疾病的强大工具。 传统的分化方案需要几种中间状态和不同的培养条件，从而无法有效地生成具有未成熟特征的神经元细胞的混合亚型。 通过强制表达神经元转录因子对PSC进行直接编程已显示出高纯度的快速细胞命运测定方法，因为它可以绕开传统培养所需的顺序发育步骤。 在这篇综述中，我们着重于通过各种转录因子将神经元从PSC分化为特定的亚型。 此外，讨论了这种新颖技术的潜在应用和局限性。

关键词: 程序设计，胚胎干细胞，多能干细胞，神经元分化，神经元，转录因子。

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