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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

AML中的免疫检查点抑制剂-一个新领域

卷 20, 期 7, 2020

页: [545 - 557] 页: 13

弟呕挨: 10.2174/1568009620666200421081455

价格: $65

摘要

尽管最近的治疗进展中，急性髓系白血病(AML)仍然是一个具有挑战性的临床实体，总体预后差。鉴于T细胞介导免疫在应对异基因干细胞移植和供体淋巴细胞灌注方面的显著作用，增强免疫激活和减轻免疫功能障碍的策略是改善AML临床结果的有吸引力的治疗平台。临床前数据显示，免疫功能障碍是AML进展和复发的主要因素。免疫检查点如程序性死亡1 (PD-1)的表达增加有助于AML免疫逃避，并与疾病进展相关。免疫检查点抑制正在探索AML的早期临床活动证据，特别是结合细胞毒性化疗和低甲基化药物。在这篇综述中，我们探索了免疫检查点抑制作为单一药物或与低甲基化药物或细胞毒性化疗联合使用背后的科学原理，并提供了AML已完成和正在进行的临床试验的最新进展。

关键词: 急性髓系白血病，免疫检查点抑制，PD-1，PD-L1，T细胞介导免疫，干细胞移植。

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