Abstract
Peptide Nucleic Acids (PNA) invented ten years ago are emerging rapidly as useful molecules in DNA hybridization and antisense techniques. Although therapeutic drugs based on PNA are still not in sight, applications in diagnostics, in particular in situ hybridization and PCR based systems, are making rapid strides. The simple structure of PNA in combination with impressive DNA mimicking properties has already provided inspiration to many synthetic organic chemists for designing and preparing several derivatives and analogs towards improving their physico-chemical and biological properties. This review which is not intended to be exhaustive, is aimed at highlighting the current progress in the areas of PNA chemistry, structure, hybridization, and applications. The various chemical backbone modifications of PNA reported till date are summarized in the context of DNA hybridization properties
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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