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Review Article

泌尿肿瘤学中的PD1/PD-L1轴

卷 21, 期 13, 2020

页: [1293 - 1300] 页: 8

弟呕挨: 10.2174/1389450121666200326123700

价格: $65

摘要

免疫系统在控制人类肿瘤的发展和进展中起着重要的作用。然而，肿瘤细胞和肿瘤微环境细胞可诱导免疫逃逸机制，包括PD-1/PD-L1等免疫检查点的激活。基于这一认识，新的免疫疗法，包括PD-1和PD-L1抑制，已经被开发出来并被推荐为转移性膀胱癌和肾癌患者的标准治疗方法。PD-L1除了作为治疗靶点的作用外，似乎也是一个预后参数，尽管数据存在争议。一方面，PD-L1在肿瘤细胞中诱导表达的信号通路及其对肿瘤细胞本身的功能作用尚不清楚。然而，对PD-L1复杂生物学功能的了解将改善泌尿系恶性肿瘤的治疗选择。本文综述了PD-1/PD-L1轴在泌尿肿瘤(包括膀胱癌、肾癌、前列腺癌、睾丸癌和阴茎癌)中的研究进展。

关键词: 检查点抑制，PD-L1，膀胱癌，前列腺癌，肾癌，睾丸生殖细胞肿瘤，阴茎癌

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