Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt

doi:10.2174/1568009620666200319102929

摘要

背景与目标: 肝细胞癌是一种侵袭性很强的癌症，治疗方法很少。toll样受体3 (TLR3)在先天免疫中发挥关键作用，可能影响癌症的发生。本研究旨在探讨TLR3基因多态性与埃及hcv相关肝癌的关系。方法: 研究对象为70人;50例丙型肝炎肝硬化患者分为两组;HCC患者(30例)和非HCC患者(20例)与20例健康对照组进行比较。所有研究对象都接受了临床实验室评估。采用聚合酶链反应-限制性片段长度多态性检测TLR3基因单核苷酸多态性(+1234C/T)。结果: 本研究报道在肝硬化HCC患者中TLR3 +1234TT基因型的患病率明显高于非HCC患者，而在对照组中未检测到。在HCC患者中分析不同临床参数的TLR3 SNP +1234C/T时，+1234C/T SNP之间存在显著相关性;即TT基因型和肝局灶性损伤“数量,大小和患者”higher Okuda 和BCLC阶段。HCC患者的年龄、性别、肝功能分级、MELD评分或AFP与TLR3 SNP无相关性。结论: TLR3基因SN P +1234C/T可能是埃及人发生hcv相关HCC的新的危险因素。

关键词: Toll样受体3，肝细胞癌，HCV，埃及，多态性，肿瘤标记。

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DOI https://dx.doi.org/10.2174/1568009620666200319102929	Print ISSN 1568-0096
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当代肿瘤药物靶点

Toll样受体3基因多态性作为埃及hcv相关性肝癌新危险因素的研究c

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当代肿瘤药物靶点

Toll样受体3基因多态性作为埃及hcv相关性肝癌新危险因素的研究c

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