Cytotoxic Dehydroabietylamine Derived Compounds

Jana	      Wiemann; Ahmed	      Al-Harrasi; René      Csuk
doi:10.2174/1871520620666200317110010
Abstract

Background and Methods: Chemotherapy remains one of the most important methods for the treatment of cancer. More recently in this context, some products derived from natural products have raised scientific interest which especially include many terpenes. Thereby, diterpenoids represent a special class, and within this class of important secondary natural products, especially compounds derived from Dehydroabietylamine (DA), are of particular interest.
Results: This review not only gives a summary of the most important findings on the cytotoxic behavior of DAderived compounds but also shows some drawbacks of these compounds, such low bioavailability and/or poor solubility of several derivatives of DA. It focusses on the chemical aspects and summarizes the DA related biological effects without deep discussion of underlying biochemical pathways.
Conclusion: Dehydroabietylamine-derived cytotoxic compounds hold a high potential to be developed into efficient antitumor active drugs.
Keywords: Dehydroabietylamine, cancer, cytotoxicity, diterpenoids, chemotherapy, natural products.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1871520620666200317110010	Print ISSN 1871-5206
Publisher Name Bentham Science Publisher	Online ISSN 1875-5992
Anti-Cancer Agents in Medicinal Chemistry

Cytotoxic Dehydroabietylamine Derived Compounds

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