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Review Article

氧甾醇与相关疾病综述

卷 28, 期 1, 2021

发表于: 16 March, 2020

页: [110 - 136] 页: 27

弟呕挨: 10.2174/0929867327666200316142659

价格: $65

摘要

本综述旨在对目前有关氧甾醇及其相关疾病的文献进行完整而全面的综述。胆固醇的氧化导致形成大量的氧化产物，一般称为氧甾醇。它们是胆汁酸、类固醇激素和1,25-二羟基维生素D3生物合成的中间体。虽然氧甾醇被认为是代谢中间体，但越来越多的证据表明其中许多是生物活性的，它们的缺乏或过量可能是疾病表型的一部分原因。这些化合物来源于胆固醇的酶或非酶氧化。这项研究提供了关于氧甾醇结构、形成和类型的全面信息，即使涉及到某些疾病状态，重点关注它们对代谢的影响以及与这些疾病的联系。特定的氧甾醇作为介质在各种疾病中的作用，如退行性(年龄相关)和癌症相关的疾病，现在已经越来越清楚。氧甾醇水平可作为诊断特定疾病或预测疾病发病率的合适指标，如糖尿病、阿尔茨海默病、多发性硬化症、骨质疏松症、肺癌、乳腺癌和不孕症。但是，可能需要进一步的调查来证实这些可能性。

关键词: 氧甾醇，胆固醇，分子靶标，疾病，病理生理学，羟基胆固醇，胆固醇排泄途径。

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