Abstract
The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.
Keywords: Polymer supported reagents, Catalysts, Synthetic application, Solution phase organic reaction, Polymer bound reagents, Mitsunobu reaction, Horner emmons reaction, Polymer bound atalysts, Nafion membrane catalysis, Resin bound cobalt II catalyst
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