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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Review Article

Chemical Metabolism of Xenobiotics by Gut Microbiota

Author(s): Radislav Nakov* and Tsvetelina Velikova

Volume 21, Issue 4, 2020

Page: [260 - 269] Pages: 10

DOI: 10.2174/1389200221666200303113830

Price: $65

Abstract

Among the gut microbiota’s newly explored roles in human biology is the ability to modify the chemical structures of foreign compounds (xenobiotics). A growing body of evidence has now provided sufficient acumen on the role of the gut microbiota on xenobiotic metabolism, which could have an intense impact on the therapy for various diseases in the future. Gut microbial xenobiotic metabolites have altered bioavailability, bioactivity and toxicity and can intervene with the actions of human xenobiotic-metabolizing enzymes to affect the destiny of other ingested molecules. These modifications are diverse and could lead to physiologically important consequences.

In the current manuscript we aim to review the data currently available on how the gut microbiota directly modifies drugs, dietary compounds, chemicals, pollutants, pesticides and herbal supplements.

Keywords: Xenobiotics, gut microbiota, drug metabolism, pollutants, bioavailability, bioactivity, toxicity.

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