Monoclonal Antibodies: A Prospective and Retrospective View

doi:10.2174/0929867327666200219142231
摘要

背景：单克隆抗体(mAbs)是生物治疗药物中最重要的一类。它们被用于治疗许多疾病，包括癌症、自身免疫疾病、心血管疾病、与血管生成有关的疾病，以及最近的血友病。它们可以在形式、来源和特异性方面高度变化，以提高疗效和获得更有针对性的应用。这可以通过基本不改变对偶类集群的基本结构组件来实现。目的：目的是追踪最相关的发现，值得多年的声望奖项，报告最重要的临床应用，并强调其最新出现的治疗趋势。结果：我们报道最相关的里程碑和新技术采用的抗体发展。简要回顾了最近在生成新的基于抗体的工程格式方面的努力。用于(或将要用于)药理实践的最重要的基于抗体的分子已收集到有用的表格中。结论：这里讨论的主题证明了单抗作为创新生物制药分子和靶向药物治疗的重要组成部分的无可争议的作用。
关键词: 治疗性单克隆抗体，抗体工程，抗体发育技术，抗体建模软件，疾病，药物治疗
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DOI https://dx.doi.org/10.2174/0929867327666200219142231	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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