Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors

Gang       Li; Wenqing       Qi; Xiaoxun       Li; Jinwu       Zhao; Meihua       Luo; Jianjun       Chen
doi:10.2174/0929867327666200210144114
Abstract

c-Jun N-Terminal Kinases (JNKs), members of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway, play a key role in the pathogenesis of many diseases including cancer, inflammation, Parkinson’s disease, Alzheimer’s disease, cardiovascular disease, obesity, and diabetes. Therefore, JNKs represent new and excellent target by therapeutic agents. Many JNK inhibitors based on different molecular scaffolds have been discovered in the past decade. However, only a few of them have advanced to clinical trials. The major obstacle for the development of JNK inhibitors as therapeutic agents is the JNKisoform selectivity. In this review, we describe the recent development of JNK inhibitors, including ATP competitive and ATP non-competitive (allosteric) inhibitors, bidentatebinding inhibitors and dual inhibitors, the challenges, and the future direction of JNK inhibitors as potential therapeutic agents.
Keywords: JNK, inhibitors, ATP binding site, JNK isoform-selective, allosteric, bidentate, Mitogen-activated Protein Kinase (MAPK).
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[http://dx.doi.org/10.1097/MAJ.0b013e3181ae9227] [PMID: 19838099] 
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DOI https://dx.doi.org/10.2174/0929867327666200210144114	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors

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