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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Phenylamino-pyrimidine (PAP) Privileged Structure: Synthesis and Medicinal Applications

Author(s): Luiz Claudio Ferreira Pimentel , Anna Claudia Cunha , Lucas Villas Boas Hoelz, Henayle Fernandes Canzian , Debora Inacio Leite Firmino Marinho, Nubia Boechat and Monica Macedo Bastos*

Volume 20, Issue 3, 2020

Page: [227 - 243] Pages: 17

DOI: 10.2174/1568026620666200124094949

Price: $65

Abstract

The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI’s with nano/picomolar activity.

Keywords: PAP, Pyrimidine, Tyrosine kinase, ATP, Cancer, Antiretroviral.

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Graphical Abstract

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