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Review Article

单胺氧化酶B抑制剂的新方面:关键作用是打开卤素的黄金大门

卷 28, 期 2, 2021

发表于: 21 January, 2020

页: [266 - 283] 页: 18

弟呕挨: 10.2174/0929867327666200121165931

价格: $65

摘要

大量的药物和有前途的铅化合物在其结构中都含有卤素。这些分子的引入强烈地调节了它们的物理化学特性以及药代动力学和药效学特征。最重要的结果是这些卤素能够通过建立卤素键对药物-靶标相互作用和活性位点内的能量稳定性产生有利的影响。这篇综述试图说明这些多功能的部分在有机支架中正确定位时所发挥的关键作用，以显示单胺氧化酶(MAO)对这种重要酶的B型异构体的抑制和选择性。人类毛蛋白被公认为情绪障碍和神经退行性疾病的治疗靶点，药物化学家发现了区分两种亚型(MAO-A和MAOB)活性位点细微差异的关键结构要求。分析最重要的支架(肼噻唑类、香豆素类、色素类、查尔酮类、吡唑啉类)的构效关系以及卤素(F、Cl、Br和I)的插入对其生物活性和同工酶选择性的影响已成为药物化学家的研究热点。

关键词: 单胺氧化酶B，抑制剂，卤素，香豆素，色酮，噻唑，查尔酮。

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