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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Research Article

Inhibition of β-amyloid Aggregation of Ugni molinae Extracts

Author(s): Daniela Jara-Moreno, Ana L. Riveros, Andrés Barriga, Marcelo J. Kogan* and Carla Delporte*

Volume 26, Issue 12, 2020

Page: [1365 - 1376] Pages: 12

DOI: 10.2174/1381612826666200113160840

Price: $65

Abstract

The β-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer’s Disease. The aim of this study was to evaluate the inhibition of β-amyloid aggregation of ethyl acetate and ethanolic extracts obtained from Ugni molinae leaves on neurotoxic actions of β-amyloid aggregates. Chemical analyses were carried out with the extracts in order to determine their phenolic profile and its quantification. Both extracts showed a tendency to reduce neuronal deaths caused by β-amyloid. This tendency was inversely proportional to the evaluated concentrations. Moreover, the effect of EAE and ETE on β-amyloid aggregation was studied by fluorimetric T Thioflavin assay and transmission electronic microscopy (TEM); the extracts showed a modulation in the aggregation process. Partly, it is believed that these effects can be attributed to the polyphenolic compounds present in the extracts.

Keywords: Ugni molinae, β-amyloid aggregation, T Thioflavin, polyphenols, β-amyloid disaggregation, fluorimetric.

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