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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives

Author(s): Stella Manta, Nikolaos Kollatos, Christos Mitsos, Georgia-Anna Chatzieffraimidi, Ioannis Papanastasiou, John K. Gallos and Dimitri Komiotis*

Volume 20, Issue 10, 2020

Page: [818 - 830] Pages: 13

DOI: 10.2174/1389557520666200103123114

Price: $65

Abstract

Pyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse routes is particularly attractive in terms of chemistry, and also from the environmental point of view. The present minireview summarizes the reported methods for the preparation of highly substituted pyrrole derivatives based on the one-pot multicomponent reaction of aldehydes, primary amines, and oxalacetate analogues as well as their biology.

Keywords: Multicomponent reaction, pyrroles, pyrrolidines, oxalacetate analogues, biological evaluation, antibacterial.

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