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ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

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Review Article

Relationship Between Atopic Dermatitis and Food Allergy

Author(s): Olga Domínguez*, Ana María Plaza and Montserrat Alvaro

Volume 16, Issue 2, 2020

Page: [115 - 122] Pages: 8

DOI: 10.2174/1573396315666191111122436

Abstract

Consistent evidence has been found on the relationship between food allergy (FA) and atopic dermatitis (AD) in some children. Food sensitization can be often found in these patients. Allergy should be confirmed, though, with a food challenge test (FC) before advising a restrictive diet which could be harmful for the patient. Younger children with AD frequently show sensitization to egg, milk or peanut, while older ones and adults are more often sensitized to environmental allergens such as house dust mites, moulds, animal dander or pollens. It is well known that a barrier disturbance plays a main role in the development of sensitization and allergy. Therefore, due to the early appearance of AD, preventive newborn skincare with emollients and early introduction of food appear to be very important to determine food tolerance.

Keywords: Atopic dermatitis, food allergy, oral food challenge, food sensitization, food-triggered atopic dermatitis.

« Previous Next »
[1]
Cipriani F, Dondi A, Ricci G. Recent advances in epidemiology and prevention of atopic eczema. Pediatr Allergy Immunol 2014; 25(7): 630-8.
[http://dx.doi.org/10.1111/pai.12309] [PMID: 25406640]
[2]
Draaisma E, Garcia-Marcos L, Mallol J, Solé D, Pérez-Fernández V, Brand PL. A multinational study to compare prevalence of atopic dermatitis in the first year of life. Pediatr Allergy Immunol 2015; 26(4): 359-66.
[http://dx.doi.org/10.1111/pai.12388] [PMID: 25845445]
[3]
Garmhausen D, Hagemann T, Bieber T, et al. Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy 2013; 68(4): 498-506.
[http://dx.doi.org/10.1111/all.12112] [PMID: 23452057]
[4]
Böhme M, Wickman M, Lennart Nordvall S, Svartengren M, Wahlgren CF. Family history and risk of atopic dermatitis in children up to 4 years. Clin Exp Allergy 2003; 33(9): 1226-31.
[http://dx.doi.org/10.1046/j.1365-2222.2003.01749.x] [PMID: 12956743]
[5]
Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest 2004; 113(5): 651-7.
[http://dx.doi.org/10.1172/JCI21060] [PMID: 14991059]
[6]
Rodríguez E, Baurecht H, Herberich E, et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009; 123(6): 1361-70.e7.
[http://dx.doi.org/10.1016/j.jaci.2009.03.036] [PMID: 19501237]
[7]
Fohr C. New insigts into the epidemiology of childhood atopic Dermatitis. Allergy 2014; 69: 3-16.
[8]
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eccema: ISAAC. Lancet 1998; 351: 1225-32.
[http://dx.doi.org/10.1016/S0140-6736(97)07302-9]
[9]
Tran MM, Lefebvre DL, Dharma C, et al. Predicting the atopic march: results from the Canadian Healthy Infant Longitudinal Development study. J Allergy Clin Immunol 2018; 141(2): 601-607.e8.
[http://dx.doi.org/10.1016/j.jaci.2017.08.024] [PMID: 29153857]
[10]
Sampson HA, Aceves S, Bock SA, et al. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol 2014; 134(5): 1016-25.e43.
[http://dx.doi.org/10.1016/j.jaci.2014.05.013] [PMID: 25174862]
[11]
Brough HA, Simpson A, Makinson K, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol 2014; 134(4): 867-875.e1.
[http://dx.doi.org/10.1016/j.jaci.2014.08.011] [PMID: 25282568]
[12]
Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol 2008; 121(6): 1331-6.
[http://dx.doi.org/10.1016/j.jaci.2008.04.032] [PMID: 18539191]
[13]
Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348(11): 977-85.
[http://dx.doi.org/10.1056/NEJMoa013536] [PMID: 12637607]
[14]
Tsakok T, Marrs T, Mohsin M, et al. Does atopic dermatitis cause food allergy? A systematic review. J Allergy Clin Immunol 2016; 137(4): 1071-8.
[http://dx.doi.org/10.1016/j.jaci.2015.10.049] [PMID: 26897122]
[15]
Kelleher MM, Dunn-Galvin A, Gray C, et al. Skin barrier impairment at birth predicts food allergy at 2 years of age. J Allergy Clin Immunol 2016; 137(4): 1111-1116.e8.
[http://dx.doi.org/10.1016/j.jaci.2015.12.1312] [PMID: 26924469]
[16]
Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O. Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 1996; 132(1): 27-33.
[http://dx.doi.org/10.1001/archderm.1996.03890250037007] [PMID: 8546480]
[17]
Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA. Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics 1998; 101(3)E8
[http://dx.doi.org/10.1542/peds.101.3.e8] [PMID: 9481027]
[18]
Burbank AJ, Burks AW. Natural history of allergic sensitization in infants with Early-Onset Atopic Dermatitis: Results from ORCA study. Pediatrics 2015; 136(6): S331.
[http://dx.doi.org/10.1542/peds.2015-2776S]
[19]
Roduit C, Frei R, Depner M, et al. Phenotypes of atopic dermatitis depend- ing on the timing of onset and progression in childhood. JAMA Pediatr 2017; 171(7): 655-62.
[http://dx.doi.org/10.1001/jamapediatrics.2017.0556] [PMID: 28531273]
[20]
Flohr C, Perkin M, Logan K, et al. Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants. J Invest Dermatol 2014; 134(2): 345-50.
[http://dx.doi.org/10.1038/jid.2013.298] [PMID: 23867897]
[21]
Sicherer SH, Sampson HA. Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management. J Allergy Clin Immunol 1999; 104(3 Pt 2): S114-22.
[http://dx.doi.org/10.1016/S0091-6749(99)70053-9] [PMID: 10482862]
[22]
Martin PE, Eckert JK, Koplin JJ, et al. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. Clin Exp Allergy 2015; 45(1): 255-64.
[http://dx.doi.org/10.1111/cea.12406] [PMID: 25210971]
[23]
Shoda T, Futamura M, Yang L, et al. Timing of eczema onset and risk of food allergy at 3 years of age: A hospital-based prospective birth cohort study. J Dermatol Sci 2016; 84(2): 144-8.
[http://dx.doi.org/10.1016/j.jdermsci.2016.08.003] [PMID: 27523805]
[24]
Böhme M, Svensson A, Kull I, Nordvall SL, Wahlgren CF. Clinical features of atopic dermatitis at two years of age: a prospective, population-based case-control study. Acta Derm Venereol 2001; 81(3): 193-7.
[http://dx.doi.org/10.1080/000155501750376294] [PMID: 11558876]
[25]
Mortz CG, Andersen KE, Dellgren C, Barington T, Bindslev-Jensen C. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy 2015; 70(7): 836-45.
[http://dx.doi.org/10.1111/all.12619] [PMID: 25832131]
[26]
Arshad SH, Tariq SM, Matthews S, Hakim E. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001; 108(2)E33
[http://dx.doi.org/10.1542/peds.108.2.e33] [PMID: 11483843]
[27]
Seo E, Yoon J, Jung S, Lee J, Lee BH, Yu J. Phenotypes of atopic dermatitis identified by cluster analysis in early childhood. J Dermatol 2019; 46(2): 117-23.
[http://dx.doi.org/10.1111/1346-8138.14714] [PMID: 30520087]
[28]
Werfel T, Breuer K. Role of food allergy in atopic dermatitis. Curr Opin Allergy Clin Immunol 2004; 4(5): 379-85.
[http://dx.doi.org/10.1097/00130832-200410000-00009] [PMID: 15349037]
[29]
Eller E, Kjaer HF, Høst A, Andersen KE, Bindslev-Jensen C. Food allergy and food sensitization in early childhood: results from the DARC cohort. Allergy 2009; 64(7): 1023-9.
[http://dx.doi.org/10.1111/j.1398-9995.2009.01952.x] [PMID: 19220211]
[30]
Werfel T, Ballmer-Weber B, Eigenmann PA, et al. Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN. Allergy 2007; 62(7): 723-8.
[http://dx.doi.org/10.1111/j.1398-9995.2007.01429.x] [PMID: 17573718]
[31]
Caffarelli C, Dondi A, Povesi Dascola C, Ricci G. Skin prick test to foods in childhood atopic eczema: pros and cons. Ital J Pediatr 2013; 39: 48.
[http://dx.doi.org/10.1186/1824-7288-39-48] [PMID: 23902622]
[32]
Robison RG, Singh AM. Controversies in allergy: Food testing and dietary avoidance in atopic dermatitis. J Allergy Clin Immunol Pract 2019; 7(1): 35-9.
[http://dx.doi.org/10.1016/j.jaip.2018.11.006] [PMID: 30501976]
[33]
Caglayan Sozmen S, Povesi Dascola C, Gioia E, Mastrorilli C, Rizzuti L, Caffarelli C. Diagnostic accuracy of patch test in children with food allergy. Pediatr Allergy Immunol 2015; 26(5): 416-22.
[http://dx.doi.org/10.1111/pai.12377] [PMID: 25808316]
[34]
Burks AW, James JM, Hiegel A, et al. Atopic dermatitis and food hypersensitivity reactions. J Pediatr 1998; 132(1): 132-6.
[http://dx.doi.org/10.1016/S0022-3476(98)70498-6] [PMID: 9470014]
[35]
Turjanmaa K, Darsow U, Niggemann B, Rancé F, Vanto T, Werfel T. EAACI/GA2LEN position paper: present status of the atopy patch test. Allergy 2006; 61(12): 1377-84.
[http://dx.doi.org/10.1111/j.1398-9995.2006.01136.x] [PMID: 17073865]
[36]
Sampson HA, Gerth van Wijk R, Bindslev-Jensen C, et al. Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol 2012; 130(6): 1260-74.
[http://dx.doi.org/10.1016/j.jaci.2012.10.017] [PMID: 23195525]
[37]
Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014; 69(8): 1008-25.
[http://dx.doi.org/10.1111/all.12429] [PMID: 24909706]
[38]
Breuer K, Heratizadeh A, Wulf A, et al. Late eczematous reactions to food in children with atopic dermatitis. Clin Exp Allergy 2004; 34(5): 817-24.
[http://dx.doi.org/10.1111/j.1365-2222.2004.1953.x] [PMID: 15144477]
[39]
de Silva D, Geromi M, Halken S, et al. Primary prevention of food allergy in children and adults: systematic review. Allergy 2014; 69(5): 581-9.
[http://dx.doi.org/10.1111/all.12334] [PMID: 24433563]
[40]
Delamere FM, Williams HC. Dietary exclusions for established atopic eczema. Cochrane Database Syst Rev 2008;CD005203. 43-Eric L. Simpson. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. JACI 2014; 134: 818.
[41]
Ito J, Fujiwara T. Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan. Ann Epidemiol 2014; 24(4): 267-72.
[http://dx.doi.org/10.1016/j.annepidem.2013.11.007] [PMID: 24342028]
[42]
Horimukai K, Morita K, Narita M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol 2014; 134(4): 824-830.e6.
[http://dx.doi.org/10.1016/j.jaci.2014.07.060] [PMID: 25282564]
[43]
Yamamoto-Hanada. PACI Study. Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy. Clin Transl Allergy 2018; 8: 47.
[http://dx.doi.org/10.1186/s13601-018-0233-8] [PMID: 30479743]
[44]
Chalmers JR, Haines RH, Mitchell EJ, et al. Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial. Trials 2017; 18(1): 343.
[http://dx.doi.org/10.1186/s13063-017-2031-3] [PMID: 28732519]
[45]
Lødrup Carlsen KC, Rehbinder EM, Skjerven HO, et al. Preventing atopic dermatitis and allergies in children the preventadall study. Allergy 2018; 73(10): 2063-70.
[http://dx.doi.org/10.1111/all.13468] [PMID: 29710408]
[46]
Jin YY, Cao RM, Chen J, et al. Partially hydrolyzed cow’s milk formula has a therapeutic effect on the infants with mild to moderate atopic dermatitis: a randomized, double-blind study. Pediatr Allergy Immunol 2011; 22(7): 688-94.
[http://dx.doi.org/10.1111/j.1399-3038.2011.01172.x] [PMID: 21539614]
[47]
Kramer MS, Kakuma R. Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child. Cochrane Database Syst Rev 2012; 9(9)CD000133
[http://dx.doi.org/10.1002/14651858.CD000133.pub3] [PMID: 22972039]
[48]
Fleischer DM. Primary prevention of allergic disease: Maternal avoidance diets in pregnancy and lactation. Up To Date 2016.
[49]
Greer FR, Sicherer SH, Burks AW. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 2008; 121(1): 183-91.
[http://dx.doi.org/10.1542/peds.2007-3022] [PMID: 18166574]
[50]
Boyle RJ, Ierodiakonou D, Khan T, et al. Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis. BMJ 2016; 352: i974.
[http://dx.doi.org/10.1136/bmj.i974] [PMID: 26956579]
[51]
von Berg A, Koletzko S, Grübl A, et al. The effect of hydrolyzed cow’s milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003; 111(3): 533-40.
[http://dx.doi.org/10.1067/mai.2003.101] [PMID: 12642834]
[52]
Osborn DA, Sinn JK, Jones LJ. Infant formulas containing hydrolysed protein for prevention of allergic disease Cochrane Database Syst Rev 2018; 10CD003664..
[http://dx.doi.org/10.1002/14651858.CD003664.pub6]
[53]
Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 2015; 372(9): 803-13.
[http://dx.doi.org/10.1056/NEJMoa1414850] [PMID: 25705822]
[54]
Perkin MR, Logan K, Tseng A, et al. Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. N Engl J Med 2016; 374(18): 1733-43.
[http://dx.doi.org/10.1056/NEJMoa1514210] [PMID: 26943128]
[55]
Turati F, Bertuccio P, Galeone C, et al. Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. Allergy 2016; 71(6): 878-88.
[http://dx.doi.org/10.1111/all.12864] [PMID: 26893011]
[56]
Natsume O, Kabashima S, Nakazato J, et al. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet 2017; 389(10066): 276-86.
[http://dx.doi.org/10.1016/S0140-6736(16)31418-0] [PMID: 27939035]
[57]
Flohr C, Mann J. New approaches to the prevention of childhood atopic dermatitis. Allergy 2014; 69(1): 56-61.
[http://dx.doi.org/10.1111/all.12343] [PMID: 24372089]
[58]
Boyle RJ, Tang ML, Chiang WC, et al. Prebiotic-supplemented partially hydrolysed cow’s milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial. Allergy 2016; 71(5): 701-10.
[http://dx.doi.org/10.1111/all.12848] [PMID: 27111273]
[59]
Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, et al. Probiotics for treating eczema. Cochrane Database Syst Rev 2018; 11CD006135
[http://dx.doi.org/10.1002/14651858.CD006135.pub3]
[60]
Fukuie T, Nomura I, Horimukai K, et al. Proactive treatment appears to decrease serum immunoglobulin-E levels in patients with severe atopic dermatitis. Br J Dermatol 2010; 163(5): 1127-9.
[http://dx.doi.org/10.1111/j.1365-2133.2010.09904.x] [PMID: 20545693]
[61]
Koji Y, Yutaka T, Megumi N, et al. Efficacy of proactive therapy to prevent incidence of food allergy against early infantile eczema: retrospective case control study. Med J Kindai Univ 2016; 41(1–2): 9-16.
[62]
Jung T, Stingl G. Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights. J Allergy Clin Immunol 2008; 122(6): 1074-81.
[http://dx.doi.org/10.1016/j.jaci.2008.09.042] [PMID: 18992925]

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