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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

定义明确的氧化石墨烯是肺癌治疗中的潜在成分

卷 20, 期 1, 2020

页: [47 - 58] 页: 12

弟呕挨: 10.2174/1568009619666191021113807

价格: $65

摘要

背景：氧化石墨烯（GO）具有独特的物理和化学性质，可用于抗癌治疗-特别是作为药物载体。由于存在多个碳原子杂化层（sp2），氧化石墨烯具有较大的表面，可高效载药。另外，GO在其表面具有大量羧基，羟基和环氧基，可以通过共价键，疏水相互作用，氢键和静电相互作用为各种药物分子充电。 目的：我们的工作目的是评估将来使用氧化石墨烯作为抗癌药物载体的可能性。 方法：在本文中，我们介绍了GO的合成，表征以及对其生物学特性的研究。测试了明确定义的氧化石墨烯对从同一器官分离的癌细胞和非恶性细胞的细胞毒性作用，这在文献中并不经常出现。 结果：进行的研究证实高浓度（> 300μgmL-1）的GO选择性降低了癌细胞系的生存能力。此外，我们表明GO片对癌细胞核有很高的亲和力，这会影响它们的代谢（抑制癌细胞增殖）。此外，我们已经证明，高浓度的GO会引起细胞膜损伤，并主要在癌细胞中低水平地产生活性氧。 结论：提出的GO可用于抗癌治疗。高浓度的GO有选择地导致肿瘤细胞死亡，而低浓度的GO可能是负载抗癌药物的潜在材料。

关键词: 氧化石墨烯，肺癌，细胞毒性，石墨烯基材料，石墨烯，药物载体。

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