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Review Article

N-乙酰半胱氨酸在精神分裂症中的作用:对敏感半胱氨酸蛋白质组的潜在作用

卷 27, 期 37, 2020

页: [6424 - 6439] 页: 16

弟呕挨: 10.2174/0929867326666191015091346

价格: $65

摘要

背景：N-乙酰半胱氨酸(NAC)在不同的精神疾病中显示了广泛的用途，包括对精神分裂症患者的有益作用。尽管谷胱甘肽的补充和NAC的抗氧化活性被认为是改善各种紊乱的机制，但似乎没有一种能足够具体地解释这些有趣的影响。一个敏感的半胱氨酸蛋白质组学作为一种新兴的功能和结构网络互联敏感半胱氨酸衍生物蛋白质(SCCP)与活性物种和半胱氨酸、谷胱甘肽循环可以调节生物能量学代谢,氧化还原体内平衡和细胞生长,分化和生存,通过不同的途径受到相同的半胱氨酸残基硫醇激进。 目的：由于这种敏感的半胱氨酸网络与帕金森氏症和阿尔茨海默氏症的发病机制有关，我回顾了在精神分裂症中起作用的蛋白质是否可以归类为敏感半胱氨酸衍生物蛋白质(SCCP)。 结果：结果表明，在精神分裂症中起作用的主要蛋白可归类为敏感半胱氨酸衍生物蛋白质(SCCP)，显示敏感的半胱氨酸蛋白质组(cysteinet)在这类精神病中存在缺陷。 结论：本综述提出，精神分裂症患者的敏感半胱氨酸蛋白质组失调是不同敏感半胱氨酸衍生物蛋白质(SCCP)功能失衡的结果，这些敏感半胱氨酸衍生物蛋白质(SCCP)在神经元和胶质细胞中发挥不同的功能。在此背景下，NAC对恢复和预防精神分裂症的作用进行了讨论。

关键词: 半胱氨酸，硫醇，反应物种，N-乙酰半胱氨酸，半胱氨酸，精神分裂症，半胱氨酸蛋白组

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