Synthesis, Electrophilic Substitution and Structure-Activity Relationship Studies of Polycyclic Aromatic Compounds Towards the Development of Anticancer Agents

Title: Synthesis, Electrophilic Substitution and Structure-Activity Relationship Studies of Polycyclic Aromatic Compounds Towards the Development of Anticancer Agents

Volume: 8 Issue: 12

Author(s): Bimal K. Banik and Frederick F. Becker

Affiliation:

Keywords: Polycyclic Aromatic, Anticancer Agents, Polycyclic aromatic hydrocarbons

Abstract: Polycyclic aromatic hydrocarbons (PAH) are considered potentially carcinogenic. Substituted PAH derivatives, in contrast, may serve as anticancer agents, and as chemotherapeutics. This article presents a review of their use. Particular emphasis is placed on the synthesis of these new compounds, electrophilic substitution reactions and novel synthetic methodologies developed in our laboratory. Based on numerous reports and the data available, we believe that DNA-intercalating and membrane-interacting sites are the target for their effects.

Cite this article as:

Banik K. Bimal and Becker F. Frederick, Synthesis, Electrophilic Substitution and Structure-Activity Relationship Studies of Polycyclic Aromatic Compounds Towards the Development of Anticancer Agents, Current Medicinal Chemistry 2001; 8 (12) . https://dx.doi.org/10.2174/0929867013372120