Multi-Epitope Vaccines (MEVs), as a Novel Strategy Against Infectious Diseases

Title:Multi-Epitope Vaccines (MEVs), as a Novel Strategy Against Infectious Diseases

Volume: 17 Issue: 5

Author(s): Mohammad Mahmoudi Goumari , Ibrahim Farhani, Navid Nezafat and Shirin Mahmoodi*

Affiliation:

• Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa,Iran

Keywords: Epitope, infectious diseases, vaccine designing, bioinformatics, Multi-epitope vaccines (MEVs), antimicrobial drugs.

Abstract: Infectious diseases have caused historical pandemics in the world. Three strategies, including sanitation programs, antimicrobial drugs, and vaccines are considered for the prevention and treatment of infectious diseases. Today, some infectious diseases cause millions of mortalities universally. Due to the emergence of antibiotic-resistant pathogens, as well as some limitations of traditional vaccines, focusing on novel strategies is essential. Multi-Epitope Vaccines (MEVs), as a novel strategy, have been designed based on immunoinformatics methods; epitope prediction by authentic servers, attachment of epitopes using proper linkers, physicochemical, immunological and structural evaluation by bioinformatics tools that are basic stages in MEVs designing. Advantages such as cost-effective, high safety, less time consumption in designing, the application of natural adjuvants, and satisfactory preclinical evaluation outstand MEVs than other types of vaccines. Therefore, MEVs are promising vaccines against resistant diseases such as lower respiratory infection and diarrhea.

Cite this article as:

Goumari Mahmoudi Mohammad , Farhani Ibrahim , Nezafat Navid and Mahmoodi Shirin*, Multi-Epitope Vaccines (MEVs), as a Novel Strategy Against Infectious Diseases, Current Proteomics 2020; 17 (5) . https://dx.doi.org/10.2174/1570164617666190919120140