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Review Article

对于DNA甲基化分析的电化学和光学生物传感策略

卷 27, 期 36, 2020

页: [6159 - 6187] 页: 29

弟呕挨: 10.2174/0929867326666190903161750

价格: $65

摘要

DNA甲基化被认为是表观遗传修饰的重要组成部分，是近几十年来的研究热点。它通常是在DNA碱基序列保持不变的情况下，一个甲基加到胞嘧啶的第5个碳原子上。DNA甲基化对维持细胞功能、遗传印迹、胚胎发育和肿瘤发生过程有重要影响，因此DNA甲基化的分析具有重要的医学意义。随着分析技术的发展和DNA甲基化研究的深入，基于生物传感技术的DNA甲基化检测策略层出不穷，以满足不同的研究需求。本文综述了近年来DNA甲基化电化学和光学生物传感分析的研究进展;此外，我们还综述了近年来利用纳米孔生物传感器等新技术检测DNA甲基化的一些进展，并重点介绍了这些方法所涉及的关键技术和生物挑战。希望本文能为DNA甲基化分析方法的选择和建立提供有益的参考。

关键词: DNA甲基化被认为是表观遗传修饰的重要组成部分，是近几十年来的研究热点。它通常是在DNA碱基序列保持不变的情况下，一个甲基加到胞嘧啶的第5个碳原子上。DNA甲基化对维持细胞功能、遗传印迹、胚胎发育和肿瘤发生过程有重要影响，因此DNA甲基化的分析具有重要的医学意义。随着分析技术的发展和DNA甲基化研究的深入，基于生物传感技术的DNA甲基化检测策略层出不穷，以满足不同的研究需求。本文综述了近年来DNA甲基化电化学和光学生物传感分析的研究进展;此外，我们还综述了近年来利用纳米孔生物传感器等新技术检测DNA甲基化的一些进展，并重点介绍了这些方法所涉及的关键技术和生物挑战。希望本文能为DNA甲基化分析方法的选择和建立提供有益的参考。 DNA甲基化，甲基化测定，电化学生物传感器，光学生物传感器，癌症诊断，表观遗传学

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