Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

doi:10.2174/0929867326666190827151741
摘要

始终需要替代和有效的药物递送方法。鼻腔可以被认为是一种非侵入性的有效给药途径。它已用于局部，全身，脑靶向和疫苗接种。尽管目前市场上有许多鼻内产品，但大多数用于本地交付，而用于其他目标的产品较少。随着纳米技术在药物输送中的应用迅速扩展，鼻腔输送作为一种有前途的方法已变得有吸引力。纳米颗粒系统促进药物穿过粘膜屏障的运输，保护药物免于鼻酶降解，增强疫苗到鼻腔淋巴组织的佐剂活性，并提供肽类进入大脑和全身循环的途径，除了具有治疗脑肿瘤的潜力。这篇综述文章旨在讨论鼻内纳米颗粒系统（包括纳米悬浮液，脂质和表面活性剂以及基于聚合物的纳米颗粒）在鼻内给药方面的潜在益处。这篇综述的目的是关注过去十年中用于鼻内递送局部，全身，大脑和疫苗接种目的的纳米技术应用的主题，涉及影响递送，监管方面和患者期望的因素。这篇评论进一步确定了在产品开发中应用按质量设计方法（QbD）的好处。根据对基于纳米技术的鼻内给药的报道研究，潜在的注意力已集中在脑靶向和疫苗给药上，并取得了可喜的结果。尽管在该领域进行了大量的研究工作，但尚无用于鼻内递送的基于纳米颗粒的产品。因此，需要进一步的努力来促进鼻内纳米颗粒产品的引入，这些产品可以在患者高度接受的情况下满足法规事务的要求。
关键词: 鼻内纳米颗粒系统，药物输送，设计质量，法规，患者期望。
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DOI https://dx.doi.org/10.2174/0929867326666190827151741	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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