Abstract
Carbazole containing alkaloids (e.g. ellipticine and related compounds, indolocarbazoles......) have caught the attention of the chemists and biochemists due to their biological activities (antitumor, antiviral, protein kinase inhibitors......). Numerous total syntheses of the natural compounds have been effected as well as structural modifications for annulating various heterocyclic systems to the carbazole. Interest in these modifications lays in the possible changes in biological activities. This review will present some of the aspects of the chemistry developped recently to introduce such modifications.
Keywords: Heterocyclic Analogues, Carbazole Alkaloids, pyranocarbazole, staurosporine, tetrahydrobenzofuranones, thienocarbazoles, Japp-Klingemann reaction, Fischer indole synthesis, antitumour activity, nitrovinylic compound
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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