Systematic Review Article

候选microRNA作为疟疾感染中的生物标志物:系统评价

卷 20, 期 1, 2020

页: [36 - 43] 页: 8

弟呕挨: 10.2174/1566524019666190820124827

价格: $65

摘要

疟疾是一个公共卫生问题,尤其是在热带国家,2017年已报告有445,000例与疟疾有关的死亡。MicroRNA(miRNA)是长度为18-24个核苷酸的小型非编码RNA,已被证明可调节基因表达。几个生物过程。 microRNA在转录过程中宿主免疫相关基因表达失调已被广泛报道在疟原虫侵袭红细胞中。候选人的miRNA将在将来和将来用作潜在的生物标记。在这项研究中,已经建立了关于miRNA作为疟疾感染候选临床生物标志物的系统评价。筛选电子数据库(Medline,EMBASE,CINAHL和Cochrane数据库),并根据既定的选择标准纳入文章。我们进行了全面搜索,以确定与疟疾和miRNA相关的出版物。遵循PRISMA指南,搜索了262篇文章,排除重复和无关的论文。该研究包括19篇文章。已发现疟疾寄生虫感染的肝脏或组织产生组织特异性miRNA,并释放到血流中。包括miR-16,miR-155,miR-150,miR-451和miR-223的miRNA与免疫相关基因表达失调的关联,例如PfEMP-1,IFN-γ,AGO-1 AGO-2;在早期,严重和/或脑部疟疾感染期间,IL4,CD80,CD86,CD36,ANG-1和ANG-2表明这些miRNA可能用作疟疾感染的生物标记。

关键词: 热带疾病,寄生虫病疟疾,恶性疟原虫,间日疟原虫系统评价,miRNA,宿主基因,生物标志物,免疫反应。

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