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Review Article

化学介质的表达与类风湿关节炎疼痛的调节相关

卷 27, 期 36, 2020

页: [6208 - 6218] 页: 11

弟呕挨: 10.2174/0929867326666190816225348

价格: $65

摘要

背景：由于自身免疫性的病理学性质，类风湿关节炎(RA)患者的疼痛处理是一个复杂的课题。研究表明，化学介质在中枢神经系统和外周神经系统不同水平疼痛的决定、易感性和调节中发挥着基础性作用，从而产生了有趣的新型分子靶点来缓解RA患者的疼痛。然而，由于类风湿性关节炎疼痛生理的复杂性和多种化学介质，一些研究的结果存在争议。 目的：这项研究的目的是确定能够调节类风湿性关节炎疼痛的化学介质。 方法：在本综述中，我们检索了PubMed、ProQuest、EBSCO和科学引文索引，以评估化学介质在调节RA疼痛方面的表达。 结果：很少有研究强调某些化学介质的表达在类风湿关节炎患者中调节疼痛的重要性。TRPV1、ASIC-3、TDV8的表达在RA中编码离子通道，调节疼痛，RA中的转录因子TNFα、TGF-β1、IL-6、IL-10、IFN-γ、IL-1b、mTOR、p21、caspase 3、EDNRB、CGRPCALCB、CGRP-CALCA、TAC1等也直接参与疼痛感知。 结论：所有化学介质的表达均与RA直接相关，通过复杂的细胞内外信号通路调节疼痛，但转录因子参与调控急性疼痛，而离子通道参与RA慢性疼痛。

关键词: 类风湿性关节炎，疼痛，转录因子，离子通道，化学介质， 伤害感受。

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