ADHD with Comorbid Bipolar Disorders: A Systematic Review of Neurobiological, Clinical and Pharmacological Aspects Across the Lifespan

doi:10.2174/0929867326666190805153610
摘要

背景：注意缺陷多动症（ADHD）是一种神经发育障碍，其特征为注意力不集中，活动过度，破坏性行为和冲动。尽管长期以来一直被认为是典型的儿童，但在过去的几十年中，ADHD症状在成年期的持续存在引起了越来越多的兴趣。确实，尽管ADHD常常与其他几种精神病合并症，尤其是双相情感障碍（BDs）并存，但ADHD的诊断极富争议，尽管这种情况使临床情况，评估和治疗变得复杂。目的：本文的目的是系统回顾整个生命周期中与BDs并存的ADHD的神经生物学，临床特征和当前药理学管理方面的科学文献，主要关注成年期。讨论：成人ADHD-BD的药理学仍是经验性的，并受临床医生个人经验的影响。兴奋剂具有迅速的功效和安全性，而非兴奋剂在检测到药物滥用史时很有用，尽管它们需要数周才能完全有效。无论如何，必须对单个人进行深入的诊断和临床评估。结论：ADHD与BD的合并症仍是一个有争议的问题，因为它是成人ADHD作为独特的疾病分类的概念。确实，尽管确实存在分歧，但一些发现强调了常见的神经生物学机制和重叠的临床特征。无论如何，在期望解决这个关键问题的同时，对这种合并症的正确管理是至关重要的，这需要情绪稳定剂的共同给药。为了更好地定义可能的治疗指南以及针对这种潜在无效病情的替代方法，对成年多动症-BD患者的大量样本进行进一步的对照临床研究显得非常紧迫。
关键词: 多动症，双相情感障碍，共病，神经生物学，药理学治疗，兴奋剂。
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DOI https://dx.doi.org/10.2174/0929867326666190805153610	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

多动症并发双相情感障碍：神经生物学，临床和药理学方面的系统评价Acro ss寿命

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当代药物化学

多动症并发双相情感障碍：神经生物学，临床和药理学方面的系统评价Acro ss寿命

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