Login Register Cart 0
Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

A Comprehensive Review on Pharmacological Properties of Abrus precatorius L.

Author(s): Vijay Chopra , Aishwarya Shriwastva, Gopal L. Khatik, Manish Vyas*, Pramod Yadav, P.K. Prajapati and Bhupendra Tomar

Volume 10, Issue 5, 2020

Page: [543 - 549] Pages: 7

DOI: 10.2174/2210315509666190801104010

Price: $65

Abstract

Background: Abrus precatorius L. (A. precatorius) is a valuable plant from the family Fabaceae which is a pea family. It is commonly known as Gunja or Jequirity, significantly found throughout India mainly Himalaya to Southern India and Ceylon. It is considered a poisonous plant due to the presence of abrin.

Objective: A. precatorius has many pharmacological and biologically active constituents, such as alkaloids, glycosides and flavonoids situated in different parts of the plant. The objective of this review is to provide a retrospective study based on its anticancer potential.

Results: Recent studies of A. precatorius are based on the isolation, characterization, and pharmacological evaluation of different secondary metabolites. These constituents possess significant cytotoxic properties against various cancer cell lines including breast, lung, liver, ovarian, prostate and leukaemia. A. precatorius is also reported to have anti-diabetic, anti-microbial, abortifacient, antioxidant, anthelmintic activity, antifertility, nephroprotective, and immunomodulatory activities.

Conclusion: The present review summarizes the anticancer potential of A. precatorius and its constituents. However, extensive research is required to establish it as a potent chemotherapeutic agent.

Keywords: Abrus precatorius, abrin, anticancer, Gunja, triterpene, chemotherapeutic agent.

Graphical Abstract

[1]
Understanding cancer the basics. Avaiable from:. https://www.webmd.com/cancer/understanding-cancer-basics
[2]
National Cancer Institute. Types of Cancer Treatment., https://www.cancer.gov/about-cancer/treatment/types
[3]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111701/
[4]
HHS Author Manuscripts., https://www.ncbi.nlm.nih. gov/pmc/articles/PMC4160808/
[5]
Solanki, A.; Zaveri, M. Pharmacognosy, phytochemistry and pharmacology of Abrus precatorius leaf: A review. Int. J. Pharm. Sci. Rev. Res., 2012, 13(2), 71-76.
[6]
Ragasa, C. Y.; Lorena, G. S.; Mandia, E. H.; Raga, D. D.; Shen, C. C. Chemical constituents of Abrus precatorius.,
[7]
Sofi, M.S.; Sateesh, M.K.; Bashir, M.; Ganie, M.A.; Nabi, S. Chemopreventive and anti-breast cancer activity of compounds isolated from leaves of Abrus precatorius L. 3 Bio-tech, 2018, 8(8), 371..
[8]
Shafi Sofi, M.; Sateesh, M.K.; Bashir, M.; Harish, G.; Lakshmeesha, T.R.; Vedashree, S.; Vedamurthy, A.B. Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231. Cytotechnology, 2013, 65(3), 407-417.
[http://dx.doi.org/10.1007/s10616-012-9494-6 ] [PMID: 23081723]
[9]
Gul, M.Z.; Ahmad, F.; Kondapi, A.K.; Qureshi, I.A.; Ghazi, I.A. Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts--An in vitro study. BMC Complement. Altern. Med., 2013, 13(1), 53.
[http://dx.doi.org/10.1186/1472-6882-13-53 ] [PMID: 23452983]
[10]
Mukhopadhyay, S.; Panda, P.K.; Das, D.N.; Sinha, N.; Behera, B.; Maiti, T.K.; Bhutia, S.K. Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase-mediated cell death. Acta Pharmacol. Sin., 2014, 35(6), 814-824.
[http://dx.doi.org/10.1038/aps.2014.15 ] [PMID: 24793310]
[11]
Sinha, N.; Panda, P.K.; Naik, P.P.; Maiti, T.K.; Bhutia, S.K. Abrus agglutinin targets cancer stem-like cells by eliminating self-renewal capacity accompanied with apoptosis in oral squamous cell carcinoma. Tumour Biol., 2017, 39(5)1010428317701634
[http://dx.doi.org/10.1177/1010428317701634 ] [PMID: 28459216]
[12]
Wu, S.; Fu, X.; Brennan, M.A.; Brennan, C.S.; Chun, C. The effects of different purifying methods on the chemical properties, in vitro anti-tumor and immunomodulatory activities of Abrus cantoniensis polysaccharide fractions. Int. J. Mol. Sci., 2016, 17(4), 511.
[http://dx.doi.org/10.3390/ijms17040511 ] [PMID: 27058538]
[13]
Yang, M.; Al Zaharna, M.; Chen, Y.S.; Li, L.; Cheung, H.Y. In vitro antioxidant activities and anti-proliferative properties of the functional herb Abrus cantoniensis and its main alkaloid abrine. Food Funct., 2014, 5(9), 2268-2277.
[http://dx.doi.org/10.1039/C4FO00217B ] [PMID: 25059572]
[14]
Ranjit, P.M.; Manasa, V.; Chowdary, Y.A.; Kiran, D.; Phani, K.; Rao, P.V.; Guntuku, G. In vitro cytotoxic activity of Abrus precatorius seed extracts against MCF-7 cell lines. Am. J. Phytomedicine. Clin. Ther., 2013, 1(8), 605-610.
[15]
Patil, A.; Vadera, K.; Patil, D.; Phatak, A.; Chandra, N. Phytochemical analysis, in vitro anticancer activity and HPTLC fingerprint profile of seeds of Abrus precatorius L. Int. J. Pharma Sci., 2015, 33(1), 262-269.
[16]
Panda, P.K.; Behera, B.; Meher, B.R.; Das, D.N.; Mukhopadhyay, S.; Sinha, N.; Naik, P.P.; Roy, B.; Das, J.; Paul, S.; Maiti, T.K.; Agarwal, R.; Bhutia, S.K. Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Mol. Carcinog., 2017, 56(2), 389-401.
[http://dx.doi.org/10.1002/mc.22502 ] [PMID: 27182794]
[17]
Garaniya, N.; Bapodra, A. Ethno botanical and phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac. J. Trop. Biomed., 2014, 4(1)(Suppl. 1), S27-S34.
[http://dx.doi.org/10.12980/APJTB.4.2014C1069 ] [PMID: 25183095]
[18]
Okhale, S.E.; Nwanosike, E.M. Abrus precatorius Linn (Fa-baceae): Phytochemistry, ethnomedicinal uses, ethnopharmacology and pharmacological activities. Int. J. Pharm. Sci. Res., 2016, 1(6), 37-43.
[19]
Adelowotan, O.; Aibinu, I.; Adenipekun, E.; Odugbemi, T. The in-vitro antimicrobial activity of Abrus precatorius (L) fabaceae extract on some clinical pathogens. Niger. Postgrad. Med. J., 2008, 15(1), 32-37.
[PMID: 18408781]
[20]
Chandraker, S.K.; Sharma, N. Abrus Precatorius L. - An important medicinal plant: A review. Int. J. Pharma. Res. Biomed. Sci., 2014, 3(4), 657-670.
[21]
Nassir, Z.S.; Sahib, H.B.; Kadhim, E.J. Phytochemical analysis and in–vitro antioxidant activity of ethanolic extract of Iraqi Abrus precatorius Linn. of leguminosae family. Int. J. Pharm. Sci. Rev. Res., 2017, 46(26), 134-138.
[22]
Ross, I.A. Medicinal plants of the world; Humana Press: New York, 2003.
[http://dx.doi.org/10.1007/978-1-59259-365-1]

Rights & Permissions Print Cite
Article Metrics
19
© 2024 Bentham Science Publishers | Privacy Policy