Search Result "time-dependent inactivation"


Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam

Journal: Drug Metabolism Letters
Volume: 3 Issue: 1 Year: 2009 Page: 45-53
Author(s): Craig Giragossian, Jennifer LaPerle, Rachel E. Kosa, Sarah Gillian

Research Article

Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme

Journal: Drug Metabolism Letters
Volume: 10 Issue: 4 Year: 2016 Page: 270-277
Author(s): Jayalakshmi Sridhar,Jiawang Liu,Rajesh Komati,Richard Schroeder,Quan Jiang,Phan Tram,Kevin Riley,Maryam Foroozesh

An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Journal: Drug Metabolism Letters
Volume: 2 Issue: 1 Year: 2008 Page: 51-59
Author(s): Loren M. Berry, Zhiyang Zhao

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 382-403
Author(s): David O. Nettleton, Heidi J. Einolf

Higher Throughput Human Hepatocyte Assays for the Evaluation of Time-Dependent Inhibition of CYP3A4

Journal: Drug Metabolism Letters
Volume: 5 Issue: 3 Year: 2011 Page: 183-191
Author(s): Albert P. Li, Utkarsh Doshi

Gene Inactivation in Caenorhabditis elegans

Journal: Current Genomics
Volume: 3 Issue: 2 Year: 2002 Page: 59-67
Author(s): Gert Jansen

Research Article

Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6

Journal: Current Drug Metabolism
Volume: 22 Issue: 11 Year: 2021 Page: 882-892
Author(s): Kehan Zhang,Yilin Li,Yao Fu,Tiantian Cui,Qian Wang,Xu Mao,Ying Peng,Jiang Zheng

Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators

Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 7-14
Author(s): Mara Livezey, Leslie D. Nagy, Laura E. Diffenderfer, Evan J. Arthur, David J. Hsi, Jeffrey M. Holton, Laura Lowe Furge

Photodynamic Inactivation of Bacteria

Journal: Current Bioactive Compounds
Volume: 2 Issue: 2 Year: 2006 Page: 127-142
Author(s): Edgardo N. Durantini

Advances in the Development of Inactivated Virus Vaccines

Journal: Recent Patents on Anti-Infective Drug Discovery
Volume: 1 Issue: 3 Year: 2006 Page: 291-296
Author(s): Fausto Stauffer, Tatiana El-Bacha, Andrea T. Da Poian

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