Search Result "kinact"
High Throughput Quantitative Assessment of CYP Inactivation Using 2 Concentration Points
Journal: Drug Metabolism Letters
Volume: 3 Issue: 2 Year: 2009 Page: 78-82
Author(s): Daniel Albaugh, Thomas Farrell, Michael Langan, W. George Lai
An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes
Journal: Drug Metabolism Letters
Volume: 2 Issue: 1 Year: 2008 Page: 51-59
Author(s): Loren M. Berry, Zhiyang Zhao
A Critical Evaluation of the Experimental Design of Studies of Mechanism Based Enzyme Inhibition, with Implications for In Vitro-In Vivo Extrapolation
Journal: Current Drug Metabolism
Volume: 7 Issue: 3 Year: 2006 Page: 315-334
Author(s): F. Ghanbari, K. Rowland-Yeo, J. C. Bloomer, S. E. Clarke, M. S. Lennard, G. T. Tucker, A. Rostami-Hodjegan
Therapeutic Drugs that Behave as Mechanism-Based Inhibitors of Cytochrome P450 3A4
Journal: Current Drug Metabolism
Volume: 5 Issue: 5 Year: 2004 Page: 415-442
Author(s): Shufeng Zhou, Eli Chan, Lee Yong Lim, Urs A. Boelsterli, Shu Chuen Li, Jiancheng Wang, Qiang Zhang, Min Huang, Anlong Xu
Higher Throughput Human Hepatocyte Assays for the Evaluation of Time-Dependent Inhibition of CYP3A4
Journal: Drug Metabolism Letters
Volume: 5 Issue: 3 Year: 2011 Page: 183-191
Author(s): Albert P. Li, Utkarsh Doshi
Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators
Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 7-14
Author(s): Mara Livezey, Leslie D. Nagy, Laura E. Diffenderfer, Evan J. Arthur, David J. Hsi, Jeffrey M. Holton, Laura Lowe Furge
Drug-Drug Interactions via Mechanism-Based Cytochrome P450 Inactivation: Points to Consider for Risk Assessment from In Vitro Data and Clinical Pharmacologic Evaluation
Journal: Current Drug Metabolism
Volume: 8 Issue: 5 Year: 2007 Page: 449-462
Author(s): Karthik Venkatakrishnan, R. Scott Obach
Suicidal Inactivation of Methemoglobin by Generation of Thiyl Radical: Insight into NAC Mediated Protection in RBC
Journal: Current Molecular Medicine
Volume: 13 Issue: 6 Year: 2013 Page: 1000-1009
Author(s): S.N. Balaji,V. Trivedi
Prediction of Drug-Drug Interactions Arising From Mechanism-Based Inactivation: Key Input Parameters and Impact on Risk Assessment
Journal: Current Drug Metabolism
Volume: 12 Issue: 9 Year: 2011 Page: 871-890
Author(s): Simon G. Wong
Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays
Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 940-951
Author(s): J. Brian Houston, Aleksandra Galetin