Search Result "intrinsic hepatic clearance"
Prediction of Human Hepatic Clearance Using an In Vitro Plated Hepatocyte Clearance Model
Journal: Drug Metabolism Letters
Volume: 3 Issue: 4 Year: 2009 Page: 296-307
Author(s): Piyun Chao, Jeffrey Barminko, Eric Novik, Yi Han, Timothy Maguire, K.-C. Cheng
Predicting Clearance in Humans from In Vitro Data
Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 334-339
Author(s): R. Scott Obach
Impact of Input Parameters on the Prediction of Hepatic Plasma Clearance Using the Well-Stirred Model
Journal: Current Drug Metabolism
Volume: 11 Issue: 7 Year: 2010 Page: 583-594
Author(s): Hong Wan, Peter Bold, Lars-Olof Larsson, Johan Ulander, Sheila Peters, Boel Lofberg, Anna-Lena Ungell, Mats Nagard, Antonio Llinas
Hepatic Elimination of Drugs in Gestational Diabetes
Journal: Current Clinical Pharmacology
Volume: 13 Issue: 1 Year: 2018 Page: 21-27
Author(s): Claudio Daniel Gonzalez,Jorge Alvarinas,Ricardo Bolanos,Guillermo Di Girolamo
Scaling In Vivo Pharmacokinetics from In Vitro Metabolic Stability Data in Drug Discovery
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 13 Issue: 2 Year: 2010 Page: 159-169
Author(s): Wendy Klopf, Philip Worboys
A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds
Journal: Drug Metabolism Letters
Volume: 10 Issue: 1 Year: 2016 Page: 3-15
Author(s): Chi-Chi Peng,Utkarsh Doshi,Chandra Prakash,Albert P. Li
A Non-acidic Sulfaphenazole Analog Demonstrating High Intrinsic Clearance and Selectivity by Canine CYP2C21
Journal: Drug Metabolism Letters
Volume: 5 Issue: 4 Year: 2011 Page: 253-258
Author(s): Charles W. Locuson, Josh F. Alfaro, Matthew J. Zaya, Denis Billen, Julie A. White, Jeffrey P. Jones
Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage: Prediction of Hepatic Drug Clearance and P450 Contribution
Journal: Current Drug Metabolism
Volume: 11 Issue: 8 Year: 2010 Page: 678-685
Author(s): Chie Emoto, Norie Murayama, Amin Rostami-Hodjegan, Hiroshi Yamazaki
Hepatic Cytochrome P450 Regulation in Disease States
Journal: Current Drug Metabolism
Volume: 2 Issue: 2 Year: 2001 Page: 165-183
Author(s): Po-Yung Cheng, Edward T. Morgan
An Estimate of the Number of Hepatocyte Donors Required to Provide Reasonable Estimates of Human Hepatic Clearance from In Vitro Experiments
Journal: Drug Metabolism Letters
Volume: 1 Issue: 2 Year: 2007 Page: 91-95
Author(s): James Byers, Kenneth Bachmann, Heather Eng, Anand Katta, Donald White, Ritwik Ghosh, Nicola J. Hewitt, Paul Silber, Genfu Chen